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INFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, André; Egger, Lotti; Alminger, Marie; Alvito, Paula; Assunção, Ricardo; Ballance, Simon; Bohn, Torsten; Bourlieu-Lacanal, ClaireDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on a...
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulati...
Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; Tomás-Barberán, Francisco A.Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary (poly)phenols revert and prevent age-related cognitive decline and neurodegeneration in model systems. However, only l...
Chemical characterization and bioactivity of phytochemicals from Iberian endemi...
Gomes, Andreia Karla; Pimpão, Rui; Fortalezas, Sofia; Figueira, Inês; Miguel, Célia; Aguiar, Carlos; Salgueiro, Lígia; Cavaleiro, CarlosAsteraceae family members are well-known for their medicinal potential, comprising several properties that make them unique among plants. Here we focus on Santolina semidentata, an endemic plant from the Iberian Peninsula, not yet described for its medicinal properties. Phytochemical characterization of S. semidentata was performed, concerning total phenol content, flavonoid content, antioxidant capacity, HPLC-...
Valuing the endangered species Antirrhinum lopesianum: neuroprotective activiti...
Gomes, Andreia Karla; Fortalezas, Sofia; Pimpão, Rui; Figueira, Inês; Maroco, João; Aguiar, Carlos; Ferreira, Ricardo B.; Miguel, CéliaPlant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented g...
B-N-Acetilhexosaminidase involvment in a-conglutin mobilization in Lupinus albus
Santos, Cláudia N.; Alves, Marta; Oliveira, António; Ferreira, Ricardo BoavidaGlycosylation is an important post-translational modification involved in the modulation of a wide variety of cellular processes. Because glycosydases are central, the aim of this study was to investigate the glycosyl activity present in the cotyledons of the seeds of an important crop legume, Lupinus albus, as well as potential natural substrates of the detected enzymes. The glycosyl activity detected in the c...
Poder antioxidante dos pequenos frutos e seus efeitos benéficos para a saúde hu...
Santos, Cláudia N.; Tavares, Lucélia; Pontes, Vera; Oliveira, Pedro; Ferreira, Ricardo BoavidaThe fruits as well as other organs of plants in its constitution have various phytochemicals, including polyphenols, the antioxidant molecules highly abundant in foods. Despite its ubiquity, its benefits to human health only start to be evaluated in 90’s, and it continues to reveal a growing interest, mainly due to epidemiological studies suggesting a link between the consumption of food and beverages rich in p...