37 documents found, page 1 of 4

Position Statement of the Immunonephrology Working Group of the Portuguese Soci...

Systemic lupus erythematosus (SLE) is a challenging immune ‑mediated disease that frequently involves the kidney as lupus nephritis (LN), an immune complex glomerulonephritis. Its occurrence is associated with increased morbidity and mortality and current treatment still fails to preserve renal function in the long term. As such, more efficacious and less toxic treatments are needed to treat LN, aiming to reduc...

Advertising in the digital age: The impact of social networks on advertising st...

In the digital age, social media has significantly transformed advertising strategies. This article examines how platforms like Facebook, Instagram, and Twitter enable precise targeting and message personalization, enhancing campaign effectiveness. The discussion adresses both opportunities, such as measurability and real-time campaign adjustments, and challenges, like the need for constant adptation to new tec...

Real-World Experience with Avacopan in ANCA-Associated Vasculitis in Portugal

Introduction: Avacopan, a selective C5a receptor inhibitor, has emerged as a potential corticosteroid-sparing treatment in ANCA-associated vasculitis (AAV). This study aims to evaluate its real-world efficacy and safety in Portuguese patients with active AAV. Methods: We conducted a multicenter retrospective analysis of 15 adult patients with newly diagnosed or relapsing AAV treated with avacopan across nine ac...

The Critical Role of Multidisciplinary Teams inthe Management of Rare Systemic ...

Rare systemic rheumatic diseases (RISD) with renal involvement, such as anti‑neutrophil cytoplasmic antibody (ANCA)‑associated vasculitis and systemic lupus erythematosus, require complex, coordinated care. These conditions often involve renal complications requiring specialized and timely intervention. Traditional care models, typically fragmented across specialties, are insufficient to meet the nuanced needs ...

The Time of Post-Truth and the Ethical Challenges in Social Intervention

In this article, the post-truth society is understood as the paradigmatic environment of today's Western societies, where, along with the feeling of risk, indifference is added to political discourses and social practices that do not correspond to factual truths. space for the flexible interpretation of policies and for the individualization of social action. In this article, we highlight the transformative pot...

A knowledge discovery methodology from EEG data for cyclic alternating pattern ...

Background: Detection and quantification of cyclic alternating patterns (CAP) components has the potential to serve as a disease bio-marker. Few methods exist to discriminate all the different CAP components, they do not present appropriate sensitivities, and often they are evaluated based on accuracy (AC) that is not an appropriate measure for imbalanced datasets. Methods: We describe a knowledge discovery met...

Experiência de ensino no jornalismo: modelo pedagógico da Universidade de Coimbra

A cortina manchada

A cortina manchada

Habitação Social, Vulnerabilidade Social e Serviço Social: Um Ensaio sobre o Fr...

As soluções implementadas ao nível das políticas atuais de habitação social têm fomentado a concentração de famílias com problemas económicos, sociais e culturais semelhantes no mesmo espaço geográfico. A intervenção dos trabalhadores sociais nestes bairros tem-se pautado por um ideal de “reabilitação” (Mendes, 1997: 73), preconizando “(…)reabilitá-los simbolicamente aos olhos da cidade, para que os próprios mo...

Writing and living on the stage of history

This article studies the intercultural trajectory of a Portuguese female aristocrat of the eighteenth to nineteenth centuries. Her trajectory of intercultural transition from a Portuguese provincial lady into an independent owner of a sugar mill in tropical Bahia is documented through family letters, which provide a polyphonic representation of a movement of personal, family, and social transculturation over al...