3 documents found, page 1 of 1
Influência da variabilidade genética do Trypanosoma cruzi na reativação da doen...
Santos, Daniela Maria dosA variabilidade genética do Trypanosoma cruzi parece correlacionar-se a algumas variáveis da doença como tropismo tecidual, infectividade e resistência a drogas. Neste estudo, clones das linhagens do T. cruzi I (Gamba cl1 e SP104 cl1 - genótipo 19) e (Cuica cl1 e P209 cl1 - genótipo 20), e do T. cruzi II (Bug2148 cl1 e MN cl2 - genótipo 39) e (MVB cl8 e IVV cl4 - genótipo 32) foram avaliadas quanto à capacidade...
Trypanosoma cruzi : genetic diversity influences the profile of immunoglobulins...
Santos, Daniela Maria dos; Silva, André Talvani Pedrosa da; Guedes, Paulo Marcos da Matta; Coelho, George Luiz Lins Machado; Lana, Marta deThe clonal evolution model postulated for Trypanosoma cruzi predicts a correlation between the phylogenetic divergence of T. cruzi clonal genotypes and their biological properties. In the present study, the linkage between phylogenetic divergence of the parasite and IgG, IgG1, IgG2a and IgG2b response has been evaluated during the acute and chronic phases of the experimental infection. Eight laboratory-cloned s...
Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in exp...
Santos, Daniela Maria dos; Martins, Tassiane Assíria Fontes; Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Coelho, George Luiz Lins MachadoThe factors involved in the reactivation of chronic Chagas disease infection are not clear enough and may be related to host immune unbalance and/or parasite genetic diversity. To evaluate the role of the Trypanosoma cruzi genetic background in the Chagas disease reactivation, we inoculated Cyclophosphamide-immunos upressed (CyI) Swiss mice with clonal stocks from T. cruzi I (Cuica cl1, P209 cl1, Gamba cl1, SP1...