6 documents found, page 1 of 1
Red seaweeds strengthening the nexus between nutrition and health: phytochemica...
Ferreira, João; Hartmann, Anja; Martins-Gomes, Carlos; Nunes, Fernando M.; Souto, Eliana B.; Santos, Dario L.; Abreu, Helena; Pereira, RuiThe red seaweeds Grateloupia turuturu and Porphyra umbilicalis are commonly used as human food, mainly in East Asia, being valuable nutritional sources. However, studies focusing on their composition and bioactivities are scarce. Thus, G. turuturu and P. umbilicalis hydroethanolic and water (infusion and decoction) extracts were prepared to characterize their bioactive compounds; assess antioxidant activity aga...
Surface engineering of silica nanoparticles for oral insulin delivery: characte...
Andreani, Tatiana; Kiill, Charlene P.; Souza, Ana Luiza R. de; Fangueiro, Joana F.; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L.The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration. Thus, a systematic physicochemical study of the surface-modified insulin-silica nan...
Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mi...
Oliveira, Paulo J.; Seiça, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardão, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The objective of this ...
Inhibitory effect of carvedilol in the high-conductance state of the mitochondr...
Oliveira, Paulo J.; Coxito, Pedro M.; Rolo, Anabela P.; Santos, Dario L.; Palmeira, Carlos M.; Moreno, António J. M.The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane, and that opening of this pore is the cause of some forms of mitochondrial dysfunction. In this work, we propose that carvedilol, a multi-role cardioprotective c...
Brain and liver mitochondria isolated from diabeticGoto-Kakizaki rats show diff...
Santos, Maria S.; Santos, Dario L.; Palmeira, Carlos M.; Seiça, Raquel; Moreno, António J.; Oliveira, Catarina R.Increased oxidative stress and changes in antioxidant capacity observed in both clinical and experimental diabetes mellitus have been implicated in the etiology of chronic diabetic complications. Many authors have shown that hyperglycemia leads to an increase in lipid peroxidation in diabetic patients and animals reflecting a rise in reactive oxygen species production. The aim of the study was to compare the su...
Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabeti...
Palmeira, Carlos M.; Santos, Dario L.; Seiça, Raquel; Moreno, António J.; Santos, Maria S.Because diabetes mellitus is associated with impairment of testicular function, ultimately leading to reduced fertility, this study was conducted to evaluate the existence of a cause-effect relationship between increased oxidative stress in diabetes and reduced mitochondrial antioxidant capacity. The susceptibility to oxidative stress and antioxidant capacity (in terms of glutathione, coenzyme Q, and vitamin E ...