18 documents found, page 1 of 2
Genomic characterisation of endangered Landim pigs reveals distinctive features...
Teixeira, Fábio; Sá, Pedro; Santos, Dulce; Garrine, Carmen; Zimba, Rosa; Augusto, Laurinda; Varela-Martinez, Varela; Chiaia, HermenegildoIntroduction: The Landim pigs of Mozambique are an important local breed, reared by smallscale farmers in extensive systems, predominantly sustained on leftover food. These pigs serve as a cornerstone of the economic stability of these communities. However, their existence is currently threatened by uncontrolled crossbreeding with commercial pig breeds. Preserving these local pigs is also crucial, given their r...
Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L.; Rosa, Maria teresa; Mendes, Ana Catarina; Santos, Dulce; Nolasco, Sofia; Graça, LuísToll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs), enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of non-mucosal DCs through TLR2 and TLR4 maintains such capacity while reinf...
Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 ce...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L. S.; Gazalle, Paula; Andaluz, Stephanie; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, DulceActivated CD4+ T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4+ T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR-activat...
Tick-borne diseases in asymptomatic cattle from São Miguel Island, Azores – A c...
Felício, Maria; Zúquete, Sara; Lima, Patrícia; Delgado, Inês; Reis, Pedro; Romão, Ricardo; Nolasco, Sofia; Santos, Dulce; Basto, Afonso; Padre, LudovinaTick-borne diseases in asymptomatic cattle from São Miguel Island, Azores – A clinical perspective Introduction/Background: The Azores archipelago is one of the regions with the highest cattle production, in Portugal. Outbreaks of tick-borne (TB) diseases have been reported by local field veterinarians and different tick species are described in São Miguel. At this study, we decided to investigate the presence ...
The apicomplexan parasite Toxoplasma gondii
Delgado, Inês; Zúquete, Sara; Santos, Dulce; Basto, Afonso Silva Pinto; Leitão, José Alexandre da Costa Perdigão e Cameira; Nolasco, SofiaToxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on a specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. gondii undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted with the feces and sporulate in the environment. In other hosts and/or tis...
The apicomplexan parasite Toxoplasma gondii
Delgado, Inês L. S.; Zúquete, Sara; Santos, Dulce; Basto, Afonso P.; Leitão, Alexandre; Nolasco, SofiaToxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on a specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. gondii undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted with the feces and sporulate in the environment. In other hosts and/or tis...
Characterization of a MOB1 homolog in the Apicomplexan parasite toxoplasma gondii
Delgado, Inês L. S.; Tavares, Alexandra; Francisco, Samuel; Santos, Dulce; Coelho, João; Basto, Afonso P.; Zúquete, Sara; Müller, JoachimMonopolar spindle One Binder1 (MOB1) proteins are conserved components of the tumor-suppressing Hippo pathway, regulating cellular processes such as cytokinesis. Apicomplexan parasites present a life cycle that relies on the parasites’ ability to differentiate between stages and regulate their proliferation; thus, Hippo signaling pathways could play an important role in the regulation of the apicomplexan life c...
Use of marble dimension stone industry (Alentejo, Portugal) by-products in the ...
Alves, Tiago; Martins, Ruben; Lopes, Luís; Gomes, Celso; Santos, Dulce; Baroso, Manuela; Rosado, FranciscoIt is well known the increasing difficulty of finding out clay deposits adequate both in quality and size, able to supply the traditional pottery industry existent in the District of Évora, Portugal. To overcome such difficulty one project was planned aiming at the use as pottery raw materials of the clay-rich “terra rossa” that overlies the marble deposits that occur in the region of the Anticlinal of Estremoz...
MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue ho...
Delgado, Inês L. S.; Carmona, Bruno; Nolasco, Sofia; Santos, Dulce; Leitão, Alexandre; Soares, HelenaThe MOB family proteins are constituted by highly conserved eukaryote kinase signal adaptors that are often essential both for cell and organism survival. Historically, MOB family proteins have been described as kinase activators participating in Hippo and Mitotic Exit Network/ Septation Initiation Network (MEN/SIN) signaling pathways that have central roles in regulating cytokinesis, cell polarity, cell prolif...
Tick (Acari: Ixodidae) infestations in cattle along Geba River basin in Guinea-...
Tudela Zúquete, Sara; Coelho, João; Rosa, Fernanda; Vaz, Yolanda; Cassamá, Bernardo; Padre, Ludovina; Santos, Dulce; P. Basto, Afonso; Leitão, AlexandreAbstract Tick infestations are a major problem for animal production in tropical areas where prevention and control remain deficient. The present study sought to assess the awareness of traditional cattle producers towards the importance of ticks and aimed at the identification of tick species infesting bovines within the Geba River basin, Guinea-Bissau. Interviews with producers revealed that the majority dire...