3 documents found, page 1 of 1
Exploring Xylella fastidiosas metabolic traits using a GSM model of the phytopa...
Oliveira, Alexandre Rafael Machado; Cunha, Emanuel Rodrigues; Silva, Miguel; Faria, Cristiana Silva; Dias, OscarXylella fastidiosa is a gram-negative phytopathogenic bacterium able to infect over 500 plant species, with devastating consequences for agricultural and forest-based economies. In the last decade, genome-scale metabolic (GSM) models have become important systems biology tools for studying the metabolic behaviour of different organisms. In this work, a GSM model of X. fastidiosa subsp. pauca De Donno is present...
Curcumin biosynthesis from ferulic acid by engineered Saccharomyces cerevisiae
Costa, João Manuel Rainha; Rodrigues, Joana Lúcia Lima Correia; Faria, Cristiana Silva; Rodrigues, L. R.Background and Goal Curcumin is a polyphenolic compound found in Curcuma longa. This bioactive molecule has several reported health-benefit effects, being the anticarcinogenic activity among the most promising ones. However, curcumin extraction from natural sources is hampered by impure products obtained from harsh chemicals and limited by plant seasonality and high prices. Therefore, curcumin heterologous prod...
Development of cell factories for the efficient production of mannosylglycerate...
Faria, Cristiana SilvaMannosylglycerate (MG) is a compatible solute implicated in the response to osmotic or heat stresses in many marine microorganisms adapted to hot environments. MG shows a remarkable ability to protect model proteins, especially against heat denaturation; however, high production costs prevented the industrial exploitation of these features. This thesis has two main objectives: i) to assess the efficacy of MG as...