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Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human h...

Barbosa, Augusto Mello Simões; Argañaraz, Enrique Roberto; Costa, Ana Maria; Rosa, Ana de Cassia Oliveira Cardoso; Alves, Nivaldo Pereira

The horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease. Minicircle integrations within LINE-1 elements create the potential for foreign DNA mobility within the host genome via the machinery associated with this retrotransposon. Here we document integration of minicircle DNA fragments i...

Date: 2011   |   Origin: Oasisbr
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