20 documents found, page 1 of 2
Portuguese Consensus for the Evaluation of the Multiple Sclerosis Treatment Res...
Batista, Sónia; Capela, Carlos; Correia, Filipe; Ferreira, João; Guimarães, Joana; Santos, Ernestina; Sá, Maria JoséIntroduction: Multiple sclerosis management has progressed significantly due to the development of novel treatments. Thus, assessing the patients’ treatment response is essential to optimize therapeutic decisions. This study aimed to establish a national consensus on the assessment and monitoring of the response to multiple sclerosis treatment with disease-modifying therapies. Methods: The Delphi methodology wa...
Multiple Sclerosis Disease-Modifying Treatment Algorithms
Capela, Carlos Miguel Cheganças; Santos, Ernestina; Palavra, Filipe; Guimarães, Joana; Cerqueira, João; Vale, José; Sousa, Lívia; Batista, SóniaFunding Information: Editorial support in the form of medical writing and editing assistance for manuscript preparation was provided by Evidenze Portugal. This article was fully supported by the Portuguese Multiple Sclerosis Study Group (GEEM), without any additional external funding. Publisher Copyright: Copyright © Ordem dos Médicos 2025.; Multiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenera...
Multiple Sclerosis Disease-Modifying Treatment Algorithms: 2025 Positioning of ...
Capela, Carlos; Santos, Ernestina; Palavra, Filipe; Guimarães, Joana; Cerqueira, João; Vale, José; Sousa, Lívia; Batista, Sónia; Sá, Maria JoséMultiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenerative disease characterized by inflammation, demyelination, and axonal/neuronal damage in the central nervous system. In Portugal, the prevalence of MS is approximately 64.4 per 100 000 individuals. It is typically diagnosed in young adults aged 30 to 40, with a higher incidence in women, although it can also affect children/adolescents and th...
Prognostic Factors Associated with Disability in a Cohort of Neuromyelitis Opti...
Moura, João; Samões, Raquel; Sousa, Ana Paula; Figueiroa, Sónia; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; Melo, Claúdia; Sousa, RaquelIntroduction: Neuromyelitis optica spectrum disorders (NMOSD) and MOG-associated disease (MOGAD) are an increasingly recognized group of demyelinating disorders of the central nervous system. Previous studies suggest that prognosis is predicted by older age at onset, number of relapses, the severity of the first attack and autoantibody status. Objective: To study prognostic factors associated with disability pr...
Neurological Involvement in a Portuguese Cohort of IgG4-Related Disease
Moura, João; Malaquias, Maria João; Jorge, Firmina; Pinto, Eduarda; Sardoeira , Ana; Laranjinha, Inês; Oliveira, Vanessa; Sousa, Ana PaulaIntroduction: Neurological involvement in immunoglobulin G4-related disease (IgG4-RD) is increasingly recognized. Its diagnosis can be challenging due to clinical mimics and difficulty in obtaining nervous system biopsies. The aim of this study was to describe a cohort of neurological IgG4-RD patients.Methods: Patients were recruited from a neuroimmunology tertiary center. Clinical, laboratory, neuroimaging and...
Síndrome de Stiff-Person: Revisão
Azevedo, Ana; Gomes, Rita; Damásio, Joana; Santos, ErnestinaStiff-person syndrome is a rare autoimmune neurologic disorder characterized by progressive muscular rigidity and painful muscle spasms predominantly affecting the axial and the proximal limb muscles. Most patients with stiff-person syndrome have antibodies directed against the glutamic acid decarboxylase, the rate-limiting enzyme for the production of inhibitory neurotransmitter gamma-aminobutyric acid. Parane...
Congenital Myasthenic Syndromes and Pregnancy Outcome
Sambayeta, Firmina; Sousa, Luísa; Ribeiro, Luís; Duarte, Sara; Silva Pinto, Carla; Martins, João; Santos, ErnestinaCongenital myasthenic syndromes (CMS) are genetic conditions characterized by dysfunction of the neuromuscular transmission. There is limited data on pregnancy safety in myasthenia gravis for both mother and child. Retrospective study on pregnant CMS patients who were followed in two tertiary hospitals and their clinical data was analyzed. Sixteen pregnancies from 9 patients with CMS and history of pregnancy we...
Diagnosis and Treatment of Neuro-Behçet: A Clinical Update
Silva, Lénia; Correia, João; Santos, ErnestinaBehçet’s disease is a relapsing multisystemic inflammatory syndrome characterized by recurrent oral and/or genital ulcers, uveitis, arthritis, skin lesions, and gastrointestinal and neurological involvement. Neuro-Behçet corresponds to nervous system involvement and is one of the most severe complications of Behçet disease. It occurs in 3% to 30% of cases and is categorized into parenchymal (most common) or non...
IMPRESS: Impact of Baseline Depression in Multiple Sclerosis Patients Starting ...
Salgado, António; Silva, Ângela; Santos, Ernestina; Flores, Catarina; Lau, RitaIntroduction: Some studies suggest an association between interferon beta (IFNβ) therapies and the development of depression symptoms in multiple sclerosis (MS). This study aimed to evaluate the impact of baseline depression (BLD) on depression score variation at 24 months (m) in MS patients starting treatment with IFNβ-1a. Methods: Multicenter, prospective, observational study in patients recently diagnosed wi...
Development and preliminary validation of the Behçet’s syndrome Overall Damage ...
Piga, Matteo; Floris, Alberto; Espinosa, Gerard; Serpa Pinto, Luísa; Kougkas, Nikolaos; Lo Monaco, Andrea; Lopalco, Giuseppe; Orlando, IdaObjective: To develop and validate the evidence-based and consensus-based Behçet's Syndrome Overall Damage Index (BODI). Methods: Starting from 120 literature-retrieved preliminary items, the BODI underwent multiple Delphi rounds with an international multidisciplinary panel consisting of rheumatologists, internists, ophthalmologists, neurologists, and patient delegates until consensus was reached on the final ...