6 documents found, page 1 of 1
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Trypanosoma cruzi : acute and long-term infection in the vertebrate host can mo...
Caldas, Sérgio; Santos, Fabiane Matos dos; Lana, Marta de; Diniz, Lívia de Figueiredo; Coelho, George Luiz Lins Machado; Veloso, Vanja MariaWe analyzed the influence of Trypanosoma cruzi maintenance in different hosts (dog and mouse) on its susceptibility to benznidazole treatment. Five T. cruzi stocks were isolated from dogs inoculated with Be-62 or Be-78 strain (both sensitive to benznidazole) 2–10 years ago, and the benznidazole sensitivity was then determined using the mouse as experimental model. The different T. cruzi stocks obtained from lon...
Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modula...
Santos, Fabiane Matos dos; Caldas, Sérgio; Cáu, Stêfany Bruno de Assis; Crepalde, Geovam Pereira; Lana, Marta de; Coelho, George Luiz Lins MachadoThrough a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40–180), as well as the time (4–18 months) necessary to induce resistance varied among the different T. cruzi stocks. The resistance phenotype r...
Evolução da cardiopatia chagásica em cães tratados com Benznidazol na fase crôn...
Santos, Fabiane Matos dosA eficácia do tratamento com Benznidazol (Bz) na fase crônica da infecção e conseqüente prognóstico da cardiopatia chagásica permanece controversa. Neste estudo foram avaliados os efeitos do tratamento com Bz na evolução da cardiopatia chagásica crônica, utilizando cães infectados com a cepa Berenice-78 como modelo experimental. Os animais infectados foram divididos em dois grupos experimentais: (i) 12 cães tra...
Avaliação da susceptibilidade/resistência ao benznidazol em populações de Trypa...
Santos, Fabiane Matos dosO objetivo deste estudo foi avaliar a possibilidade de indução de resistência ao benznidazol de populações do Trypanosoma cruzi consideradas 100% sensíveis ao fármaco. Para isto, foram utilizados camundongos Swiss infectados com cinco (Be-62A, Be-62B, Be-78C, Be-78D e Be-78E) populações do T. cruzi, obtidas de diferentes cães chagásicos crônicos infectados com as cepas do T. cruzi Be-62 e Be-78, ambas 100% sens...