9 documents found, page 1 of 1
Could poor waste management be an additional factor for the spread of COVID-19?...
Mol, Marcos Paulo Gomes; Caldas, Sérgio; Pereira, Cristiane Mendes; Silva, Marcos Vinícius Ferreira; Piedade, Josiane BarbosaCOVID-19 is a new coronavirus respiratory disease caused by SARS-CoV-2, first described in China in December 2019 and since March 2020 has been affecting the whole world. The principal mode of transmission is through exposure to respiratory droplets carrying infectious virus. Contact with contaminated surfaces or objects (fomites) is also possible, although the risk is generally considered low. However, the wid...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Myocarditis in different experimental models infected by Trypanosoma cruzi is c...
Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Guedes, Paulo Marcos da Matta; Nascimento, Álvaro Fernando da Silva do; Galvão, Lúcia Maria da CunhaThis study was designed to verify the relationship between IgG antibodies isotypes and myocarditis inTrypanosoma cruzi infection using mice and dogs infected with different T. cruzi strains. The animals wereinfected with benznidazole-susceptible Berenice-78 and benznidazole-resistant AAS and VL-10 strains.The IgG subtypes were measured in serum samples from dogs (IgG, IgG1, and IgG2) and mice (IgG, IgG1,IgG2a, ...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Real-time PCR strategy for parasite quantification in blood and tissue samples ...
Caldas, Sérgio; Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Lima, Wanderson Geraldo de; Oliveira, Riva de Paula; Cecílio, Alzira BatistaThe lack of an accurate diagnosis has been a serious obstacle to the advancement of the anti-Trypanosoma cruzi chemotherapy and long-term infection can result in different health risks to human. PCRs are alternative methods, more sensitive than conventional parasitological techniques, which due to their low sensitivities are considered unsuitable for these purposes. The aim of this study was to investigate a se...
Trypanosoma cruzi : acute and long-term infection in the vertebrate host can mo...
Caldas, Sérgio; Santos, Fabiane Matos dos; Lana, Marta de; Diniz, Lívia de Figueiredo; Coelho, George Luiz Lins Machado; Veloso, Vanja MariaWe analyzed the influence of Trypanosoma cruzi maintenance in different hosts (dog and mouse) on its susceptibility to benznidazole treatment. Five T. cruzi stocks were isolated from dogs inoculated with Be-62 or Be-78 strain (both sensitive to benznidazole) 2–10 years ago, and the benznidazole sensitivity was then determined using the mouse as experimental model. The different T. cruzi stocks obtained from lon...
Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modula...
Santos, Fabiane Matos dos; Caldas, Sérgio; Cáu, Stêfany Bruno de Assis; Crepalde, Geovam Pereira; Lana, Marta de; Coelho, George Luiz Lins MachadoThrough a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40–180), as well as the time (4–18 months) necessary to induce resistance varied among the different T. cruzi stocks. The resistance phenotype r...
Alteração natural do padrão de susceptibilidade ao benznidazol em populações de...
Caldas, SérgioNeste trabalho foi investigada a influência da manutenção do Trypanosoma cruzi na fase crônica ou aguda da infecção, em diferentes hospedeiros vertebrados, em relação às características biológicas do parasito. Para isso, camundongos Swiss foram inoculados com cinco isolados do T. cruzi (Be-62A e B, e Be-78C, D e E) obtidos de diferentes cães chagásicos crônicos infectados com as cepas parentais Be-62 e Be-78, a...
Avaliação comparativa do tratamento com derivados nitroimidazólicos e triazólic...
Caldas, SérgioA doença de Chagas é causada pelo protozoário Trypanosoma cruzi e afeta milhões de pessoas as quais podem desenvolver alterações cardíacas e digestivas. Decorridos mais de 100 anos da descrição do primeiro caso clínico da enfermidade, a cura é ainda um desafio. A necessidade de novas alternativas de tratamento é clara, mas os investimentos globais em pesquisa e desenvolvimento de fármacos são insuficientes, pri...