9 documents found, page 1 of 1

Neuromodulation of acid-sensitive ion channels (ASICs) and anti-inflammatory po...

The xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by ...

Chemical prospecting and antioxidant, anticholinesterase and antifungal activit...

The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AC...

Knowing Robotox: A profile of monitoring and releasing pesticides in Brazil

Pesticides are products intended for the production sector, whose purpose is to preserve ecosystems by altering the composition of flora or fauna in order to preserve them from the harmful action of living beings considered harmful. The insertion of pesticides in Brazil is due to the Green Revolution, the mechanization and the intense use of agricultural inputs. As a result, damage to workers' health and the en...

Antibacterial and antioxidant activities of Derriobtusone A isolated from Lonch...

This study evaluated the effect of derriobtusone A, a flavonoid isolated from Lonchocarpus obtusus, on two important pathogenic bacteria, Staphylococcus aureus and Escherichia coli, as well as its antioxidant activity and toxicity. Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated. In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferro...

Effect of a casbane diterpene isolated from Croton nepetaefolius on the prevent...

This study aimed to evaluate the effect of the compound 1,4-dihydroxy-2E,6E,12E-trien-5-one-casbane (CD1CN), a casbane diterpene isolated from Croton nepetaefolius stalks, on the biofilm formation or preformed biofilms of bacteria and yeasts. Minimum inhibitory concentration results showed that CD1CN inhibited the growth of single cultures of Staphylococcus aureus and Candida albicans at 125 and 500 g/mL, respe...

Casbane diterpene activity on mixed biofilms of P. aeruginosa and Candida species

Prophylactic outcomes of casbane diterpene in Candida albicans and Candida glab...

Biofilms are surface associated communities of microorganisms embedded within a self-produced extracellular matrix and adhered on inert and biotic surfaces. These biological consortia are considered the most prevalent growth form of microorganisms. Biofilm formation is a potent virulence factor for a number of Candida species, as it confers significant tolerance to antimicrobial therapy, primarily by limiting t...

Casbane diterpene as a promising natural antimicrobial agent against biofilm-as...

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit mi...

Casbane diterpene as novel and natural antimicrobial agent against biofilm infe...

Croton nepetaefolius is a plant native from northeastern Brazil and belongs to Euphorbiaceae family. The essential oil of this plant is widely used in folk medicine from the treatment of gastrointestinal disorders to the use as an antiseptic agent, with an antifungal action scientifically proven. The action of this plant has been extensively explored by the scientific community, being the secondary metabolites,...