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Nano-in-Micro GelMA depots assist electro-thermal-immuno orchestral treatment f...
Li, Jiachen; Zhuang, Yaping; Han, Huijie; Zhu, Yuewen; Lin, Chao; Wang, Rui; Silva, Ana Catarina Rodrigues da; Stuart, Marc C. A.; Jiang, GuimeiTriple-negative breast cancer (TNBC) exhibits high local-recurrence risk despite modern systemic therapy assisted with surgery or irradiation therapy. Here, we report an injectable nano-in-micro microsphere depot (cPAG) that integrates conductivity enhancement, photothermal conversion, O2 and reactive oxygen species (ROS) generation, and innate immune agonist co-delivery to support staged, local multimodal ther...
Engineered shape-tunable copper-coordinated nanoparticles for macrophage reprog...
Gao, Han; Cheng, Ruoyu; Cardoso, Inês; Lobita, Maria; Pacheco-Fernández, Idaira; Bártolo, Raquel; Rodrigues, L. R.; Hirvonen, Jouni; Santos, Hélder A.The immune system safeguards as primary defense by recognizing nanomaterials and maintaining homeostasis, gaining a deeper understanding of these interactions may change the treating paradigm of immunotherapy. Here, we adopted copper as the principal component of nanoparticles (NPs), given its features of coordination with different benezenecarboxylate ligands to form metalorganic frameworks and complexes with ...