12 documents found, page 1 of 2

Exploring the hypocholesterolemic potential of a fucus vesiculosus extract: Omi...

High blood cholesterol levels are a major risk factor for cardiovascular diseases. A purified aqueous extract of Fucus vesiculosus, rich in phlorotannins and peptides, has been described for its potential to inhibit cholesterol biosynthesis and intestinal absorption. In this work, the effect of this extract on intestinal cells' metabolites and proteins was analysed to gain a deeper understanding of its mode of ...

Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omi...

High blood cholesterol levels are a major risk factor for cardiovascular diseases. A purified aqueous extract of Fucus vesiculosus, rich in phlorotannins and peptides, has been described for its potential to inhibit cholesterol biosynthesis and intestinal absorption. In this work, the effect of this extract on intestinal cells' metabolites and proteins was analysed to gain a deeper understanding of its mode of ...

Mass spectrometry‑based identification of peptides presented by major histocomp...

Immunopeptidomics is a field of research that has progressed in thelast years due to advances in sophisticated analytical techniquesbased on mass spectrometry and bioinformatics. The ability to identifymolecules to the extent of a single ion led to a step forward inimmunopeptidomics. Mass spectrometry enables the identificationof thousands of peptide sequences in a single sample, thus providinglarge-scale relia...

Identification of peptides presented by major histocompatibility complex in mac...

How to dissect viral infections and their interplay with the host-proteome by i...

The capabilities of bioanalytical mass spectrometry to (i) detect and differentiate viruses at the peptide level whilst maintaining high sample throughput and (ii) to provide diagnosis and prognosis for infected patients are presented as a tutorial in this work to aid analytical chemists and physicians to gain insights into the possibilities offered by current high-resolution mass spectrometry technology and bi...

Multiomics Substrates of Resistance to Emerging Pathogens? Transcriptome and Pr...

Antibiotic resistance and hospital acquired infections are on the rise worldwide. Vancomycin-resistant enterococci have been reported in clinical settings in recent decades. In this multiomics study, we provide comprehensive proteomic and transcriptomic analyses of a vancomycin-resistant Enterococcus faecalis clinical isolate from a patient with a urinary tract infection. The previous genotypic profile of the s...

Multiomicssubstrates of resistance to emerging pathogens? transcriptome and pro...

Antibiotic resistance and hospital acquired infections are on the rise worldwide. Vancomycin-resistant enterococci have been reported in clinical settings in recent decades. In this multiomics study, we provide comprehensive proteomic and transcriptomic analyses of a vancomycin-resistant Enterococcus faecalis clinical isolate from a patient with a urinary tract infection. The previous genotypic profile of the s...

Copper Complexes with 1,10-Phenanthroline Derivatives: Underlying Factors Affec...

The interpretation of in vitro cytotoxicity data of Cu(II)-1,10-phenanthroline (phen) complexes normally does not take into account the speciation that complexes undergo in cell incubation media and its implications in cellular uptake and mechanisms of action. We synthesize and test the activity of several distinct Cu(II)-phen compounds; up to 24 h of incubation, the cytotoxic activity differs for the Cu comple...

Meander-line monopole antenna with compact ground plane for a bluetooth system-...

In this letter, a packaged compact meander-line monopole antenna for Bluetooth communications, manufactured in low-density fan-out technology, is presented. A combined size for the antenna and ground plane of 0.1 lambda(0) x 0.06 lambda(0) x 0.008 lambda(0) is obtained. Such small antennas are usually designed considering their connection to an evaluation board with a large ground plane, which improves their ga...

Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Produ...

Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strain C999 was isolated of a Spanish patient with urinary tract infection. Previous genotyping indicated that this strain presented a multidrug-resistance phenotype and carried beta-lactamase genes encoding CTX-M-15, TEM-1, and OXA-1 enzymes. The whole-cell proteome, and the membrane, cytoplasmic, periplasmic and extracellular sub-proteomes of ...