5 documents found, page 1 of 1
Lysophosphatidylcholine induces NLRP3 inflammasome-mediated foam cell formation...
Corrêa, Rafael; Silva, Luís Felipe Fonseca; Ribeiro, Dalila Juliana Silva; Almeida, Raquel das Neves; Santos, Igor de Oliveira; Corrêa, Luís HenriqueFoam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of proinflammatory activities and plays a key role in atherosclerosis. However, the role of LPC in lipid droplet (LD) biogenesis and the modulation of inflammasome activation...
The use of the anticoagulant heparin and corticosteroid dexamethasone as promin...
Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Nascimento, Gabriel Pasquarelli do; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19 is spreading worldwide at disturbing rates, overwhelming global healthcare. Mounting death cases due to disease complications highlight the necessity of describing efficient drug therapy strategies for severe patients. COVID-19 severity associates with hypercoagulation and exacerbated inflammation, both influenced by ACE2 downregulation and cytokine storm occurrence. In this review, we discuss the appl...
Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) ...
Melo, Heloísa Antoniella Braz de; Nascimento, Gabriel Pasquarelli do; Corrêa, Rafael; Almeida, Raquel das Neves; Santos, Igor de OliveiraZika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still ...
Hypercoagulopathy and adipose tissue exacerbated inflammation may explain highe...
Nascimento, Gabriel Pasquarelli do; Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious ou...
Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative b...
Pizato, Nathalia Marcolini Pelucio; Luzete, Beatriz Christina; Kiffer, Larissa Fernanda Melo Vasconcelos; Corrêa, Luís HenriqueThe implication of inflammation in pathophysiology of several type of cancers has been under intense investigation. Omega-3 fatty acids can modulate inflammation and present anticancer effects, promoting cancer cell death. Pyroptosis is an inflammation related cell death and so far, the function of docosahexaenoic acid (DHA) in pyroptosis cell death has not been described. This study investigated the role of DH...