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Five decades of groundwater change across a diverse Mediterranean climate regio...
Costa, Diogo; Santos, João; Chambel, AntónioGroundwater systems in Mediterranean regions are under increasing pressure from climate variability and human activities, yet long-term, large-scale assessments of water quality dynamics remain scarce. This study compiles and analyses over 4.4 million observations collected from 2,501 monitoring stations across Portugal, covering an area of 89,015 km2 over a 3.5-decade period (1970–2024), and encompassing 15 na...
Development and evaluation of a principal component-based composite drought ind...
Raziei, Tayeb; Miri, Morteza; Santos, João; Zand, Mehran; Pereira, Luis S.This study introduces a composite drought index (CDI) that integrates multiple drought indices, including the Simplified Standardized Precipitation Index (SSPI), Simplified Standardized Precipitation-Evapotranspiration Index (SSPEI), soil moisture measured at depths of 0–10 cm (SM1) and 10–40 cm (SM2), Normalized Difference Vegetation Index (NDVI), and Vegetation Health Index (VHI), using principal component an...
A transformação dos votos em mandatos: O sistema eleitoral português em análise
Santos, JoãoA comemoração dos 50 anos da Revolução de Abril tem sido favorável à realização de uma série de balanços relativos aos elementos definidores da democracia portuguesa. Neste sentido, o presente Working Paper carateriza o sistema eleitoral português e avalia a performance do mesmo ao longo do seu quase meio século de existência. O desempenho do sistema eleitoral foi medido através da definição de três critérios-c...
Distributed composite drought index based on principal component analysis and t...
Carriço, Nelson; Miri, Morteza; Raziei, Tayeb; Santos, JoãoA variety of drought indices were developed to monitor different types of drought, a significant natural hazard with multidimensional impacts. However, no single drought index can capture all dimensions of drought, necessitating a composite drought index (CDI) that integrates a range of indicators. This study proposes a CDI using principal component analysis (PCA) and a temporal dependence assessment (TDA) appl...
PLGA nanoparticles double-decorated with a TAT peptide and folic acid to target...
Andrade, Stéphanie; Ramalho, Maria J.; Santos, João; Santos, Sílvio Roberto Branco; Melo, Luís Daniel Rodrigues; Guimarães, Nuno; Ferraz, Maria P.Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing bacterial membranes permeability while specifically targeting Staphylococcus aur...
Energy sustainability in the ripening of traditional cheese: Renewable energy s...
Santos, João; M. Garcia, João; Dias, João; Martins, João; Alvarenga, Nuno; M. Gonçalves, Elsa; Freitas, Daniela; Silvério, Karina; Fernandes , JaimeImproving the energy efficiency of traditional production methods while preserving their cultural and economic value is a challenge aligned with the Sustainable Development Goals of the 2030 agenda. Refrigeration during cheese maturation is particularly energy-intensive, contributing significantly to greenhouse gas emissions and operating costs. An approach to make traditional cheese production more sustainable...
SCIENTIFIC REPRODUCIBILITY IN THE AGE OF ARTIFICIAL INTELLIGENCE: LEGAL CHALLEN...
Sampaio, Giovanna; Santos, João; Assis, BrunoScientific reproducibility has become a central theme amidst the crisis affecting various fields of knowledge, especially in the era of artificial intelligence (AI). This paper analyzes the technical, legal, and ethical challenges related to reproducibility, focusing on the interaction between AI, intellectual property, copyrights, patents, and the Brazilian General Data Protection Law (LGPD). The impact of AI ...
Five decades of groundwater change across a diverse Mediterranean climate regio...
Costa, Diogo; Santos, João; Chambel, AntónioGroundwater systems in Mediterranean regions are under increasing pressure from climate variability and human activities, yet long-term, large-scale assessments of water quality dynamics remain scarce. This study compiles and analyses over 4.4 million observations collected from 2,501 monitoring stations across Portugal, covering an area of 89,015 km2 over a 3.5-decade period (1970–2024), and encompassing 15 na...
The impact of a rectal spacer in VMAT Dosimetry in the treatment of Prostate Ca...
Oliveira, Susana; Fernandes, Ruben; Baylina, Pilar; Santos, João; Vieira, Guy; Faria, Isabel; Pereira, Norberto; Fernandes, RúbenAlthough the dosimetric advantages of rectal spacers in prostate cancer radiotherapy have been demonstrated in selected clinical trials, real-world data from routine clinical practice remain limited—particularly within the Portuguese healthcare system. This study offers a detailed dosimetric comparison of Volumetric Modulated Arc Therapy (VMAT), with and without rectal spacer use, in a real-world patient cohort...
Proposal for upcycling sparkling winemaking waste for oenogastronomy tourism
Flores, Catarina; Ribeiro, Tamara; Santos, João; Prista, Catarina; Botelho, GoretiIntroduction: Oenogastronomic tourism is increasingly focusing on the circular economy and sustainability. After the second alcoholic fermentation in the bottle, the yeast encapsulated in calcium alginate beads used in sparkling wine production loses viability and is discarded by the wineries. Objective: This work explored the potential of the Triple Layer Business Model Canvas (TLBMC) as a support to develop s...