22 documents found, page 1 of 3
Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...
Afonso, Julieta Alexandra Pereira; Matos, Ana Catarina Barbosa; Silvestre, Ricardo Jorge Leal; Pereira-Vieira, Joana; Gonçalves, Samuel MartinsAdvanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...
MicroRNAs Biomarkers for Early Screening of Colorectal Cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísBackground: Colorectal cancer (CRC) is the most incident neoplasia in Portugal [1]. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions [3, 4]. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (mi...
Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as progn...
Afonso, Julieta; Gonçalves, Céline; Costa, Marta; Ferreira, Débora Carina Gonçalves Abreu; Santos, Lúcio; Longatto-Filho, Adhemar; Baltazar, FátimaProliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed to validate the glycolysis-related proteins as prognostic/predictive biomarkers in urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates and poor response to chemotherapy. Here, we assessed GLUT1, HK2, PFKL...
MicroRNAs biomarkers for early screening of colorectal cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) is the most incident neoplasia in Portugal. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (miRs) play a role in gene...
MicroRNA biomarkers as promising tools for early colorectal cancer screening—a ...
Santos, Daniela A. R.; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Early detection of this neoplasia has proven to improve prognosis, resulting in a 90% increase in survival. However, available CRC screening methods have limitations, requiring the development of new tools. MicroRNA biomarkers have emerged as a powerful screening tool, as they are highly expressed in CRC patients and easily detectable i...
First record of Achatina fulica Bowdich, 1822 (Mollusca, Achatinidae), for the ...
Arruda, Janine Oliveira; Santos, LúcioAchatina fulica Bowdich, 1822, is here officially recorded for the first time for Rio Grande do Sul State, Brazil. It is now known to occur in every Brazilian state. The species is on the list of the 100 worst invasive species in the world. One young specimen of giant African snail was found in a garden of a residential building in the municipality of Porto Alegre. A hypothesis is that it was accidentally intro...
CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cispla...
Afonso, Julieta Alexandra Pereira; Santos, Lúcio; Gonçalves, Vera M.; Morais, António; Amaro, T.; Longatto Filho, Adhemar; Baltazar, FátimaThe relapsing and progressive nature of bladder tumors, and the heterogeneity in the response to cisplatin-containing regimens, are the major concerns in the care of urothelial bladder carcinoma (UBC) patients. The metabolic adaptations that alter the tumor microenvironment and thus contribute to chemoresistance have been poorly explored in UBC setting. We found significant associations between the immunoexpres...
Conectividade de hábitat em bacias hidrográficas : simulações com múltiplas bar...
Santos, LúcioA biodiversidade dos rios brasileiros encontra-se sob severa ameaça, em razão da fragmentação e perda de hábitat que os barramentos representam. Até o presente, os aproveitamentos hidrelétricos têm seu licenciamento ambiental condicionado a análises de impacto locais, sem avaliação dos impactos cumulativos de múltiplas barragens em uma bacia hidrográfica, com relação à conservação da diversidade da ictiofauna. ...
A step towards personalized medicine: establishment of a pharmacogenomics profi...
Lima, Luís; Ferreira, José A.; Medeiros, Rui; Santos, LúcioThe most effective adjuvant therapy of non-muscle invasive bladder cancer (NMIBC) during the last 35 years has been the intravesical instillation with Bacillus Calmette-Guerin (BCG). However, despite its efficacy, approximately 30% of the patients present treatment failure and tumor may progress.
Evolução técnica em olivicultura
Barroso, João; Peça, José; Dias, António; Pinheiro, Anacleto; Santos, Lúcio“O Grande Livro da Oliveira e do Azeite – Portugal Oleícola”, cujo autor-coordenador foi o Comendador Jorge Bohm, tem inserido no tema “Evolução técnica em olivicultura” o capítulo da evolução técnica em olivicultura, em que são abordados os seguintes aspectos: - Tecnologias culturais; - Mecanização; - Importância da rega no olival - Conceitos e prática. Em cada um dos aspectos anteriores são apresentadas as so...