7 documents found, page 1 of 1
IPOscore: an interactive web-based platform for postoperative surgical complica...
Mochão, Hugo; Gonçalves, Daniel; Alexandre, Leonardo; Castro, Carolina; Valério, Duarte; Barahona, Pedro; Moreira-Gonçalves, Daniel; Costa, Paulo M.Background: The performance of traditional risk score systems to predict (post)-operative outcomes is limited. This weakness reduces confidence in its use to support clinical risk mitigation decisions. However, the rapid growth of health data in the last years offers principles to deal with some of these limitations. In this regard, the data allows the extraction of relevant information for both patients strati...
Association between estrogen receptors and GATA3 in bladder cancer: a systemati...
Bernardo, Carina; Monteiro, Fátima L.; Direito, Inês; Amado, Francisco; Afreixo, Vera; Santos, Lúcio L.; Helguero, Luisa A.Background: Estrogen receptors alpha (ERα) and beta (ERβ) and the cooperating protein GATA-binding factor 3 (GATA3) have been implicated in bladder carcinogenesis and tumour progression. GATA3 and ER have been functionally linked in the establishment of luminal fate in breast tissue, but to date their relationship in bladder cancer has not been established. This information will be useful to advance diagnostic ...
Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microf...
Carvalho, Sandra; Abreu, Catarina M.; Ferreira, Dylan; Lima, Luís; Santos, Lúcio L.; Ribeiro, Ricardo; Grenha, Vânia; Martínez-Fernández, MónicaBladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrich...
Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen r...
Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; Félix, Vítor; Afreixo, VeraEstrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive. We evaluated ERα and ERβ expression in UGS-related BlaCa (n = 27),...
Estrogen receptors in urogenital schistosomiasis and bladder cancer: estrogen r...
Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; Félix, Vítor; Afreixo, VeraEstrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive. We evaluated ERα and ERβ expression in UGS-related BlaCa (n = 27),...
Metabolic coupling in urothelial bladder cancer compartments and its correlatio...
Afonso, Julieta Alexandra Pereira; Santos, Lúcio L.; Morais, A.; Amaro, Teresina; Longatto Filho, Adhemar; Baltazar, Maria de Fátima MonginhoMonocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. These molecules are key players of the metabolic reprogramming of cancer cells, and evidence indicates a potential contribution in urothelial bladder cancer (UBC) aggressiveness and chemoresistance. However, the specific role of MCTs in the metabolic compartmentalization within bladd...
Low RKIP expression associates with poor prognosis in bladder cancer patients
Afonso, Julieta Alexandra Pereira; Longatto Filho, Adhemar; Martinho, Olga; Lobo, Francisco; Amaro, Teresina; Reis, R. M.; Santos, Lúcio L.Urothelial bladder cancer (UBC) is a heterogeneous type of disease. It is urgent to screen biomarkers of tumour aggressiveness in order to clarify the clinical behaviour and to personalize therapy in UBC patients. Raf kinase inhibitory protein (RKIP) is a metastasis suppressor, and its downregulation is associated with metastatic events in an increasing number of solid tumours. We evaluated the clinical and pro...