30 documents found, page 1 of 3

A preliminary assessment of a stool-based microRNA profile for early colorectal...

Colorectal cancer screening methods are well established worldwide as a fundamental pilar in CRC management, namely through non-invasive faecal occult blood testing. However, the limited sensitivity of faecal occult blood test for detecting precancerous lesions highlights the need to search for alternative tools, such as microRNAs (miRs). The main aim of this study was to identify stoolbased miR profiles for ea...

Deciphering the influence of CD276 glycocode in gastric cancer immunoregulation

Gastric cancer (GC) ranks 5th globally in incidence and cancer-related mortality, with advanced-stage 5-year survival rates below 20%1,2, unveiling the need for novel immunotherapies. CD276, an immune checkpoint molecule, is related to immune evasion and tumour progression in GC3-5. In turn, aberrant glycosylation, especially truncated O-glycans, Tn and Sialyl-Tn, correlates with GC aggressiveness and poor prog...

Oncology in the PALOP: a growing challenge

Oncology represents a significant challenge for global public health. In the Portuguese-Speaking African Countries (PALOP), this reality is no different. Cancer not only has a devastating impact on patients but also on their families. The increasing number of cases is putting pressure on the healthcare systems of these nations, which are mostly overwhelmed by infectious diseases and other chronic illnesses. Thi...

RADIATION-INDUCED SARCOMAS: A SURGICAL CHALLENGE

Malignant peripheral nerve sheath tumors (MPNST) are uncommon, biologically challenging soft tissue sarcomas. The definitive treatment of these tumors is extremely challenging. In 50% of cases, these tumors are associated with type I neurofibromatosis, but in some cases, the cause can be previous treatment with radiotherapy. The present article pretends to report a clinical case of a radiation-induced MPNST sub...

EVALUATION OF THE COSTS OF COLORECTAL CANCER TREATMENT ACCORDING TO PHASE OF CA...

Background: Colorectal cancer is the second most common cancer in Portugal, which imposes an economic burden in the restricted health care budget. The aim of this study was to estimate the effects of age, stage, gender, Eastern Cooperative Oncology Group performance status, Charlson Comorbidity Index and category of health care activity on the average colorectal cancer treatment costs based on hospital records ...

HIV And Esophageal Cancer In Mozambique: What Can We Learn?

Esophageal cancer (EC) is a common cancer in Mozambique, with esophageal squamous cell carcinomas (ESCC) being the most frequent subtype of this cancer. Little is known about the impact of the human immunodeficiency virus (HIV) on this pathology. The main goal of this study was to assess the association between EC and HIV infection. Methods: A case-control study was conducted, in 2018, at Maputo Central Hospita...

Identification Of The Crucial Pieces Of Esophageal Cancer Prevention And Early ...

Esophageal squamous cell carcinoma (ESCC) poses a significant health burden in Mozambique, with high incidence rates and late-stage diagnoses contributing to its lethality. This comprehensive review examines the epidemiology, risk factors, and potential preventive strategies for ESCC in Mozambique. Key risk factors identified include tobacco smoking, alcohol consumption, dietary factors, hot beverage consumptio...

Editorial

Neoadjuvant gastric cancer treatment and associated nutritional critical domain...

(1) Background: Gastric cancer patients are known to be at a high risk of malnutrition, sarcopenia, and cachexia, and the latter impairs the patient’s nutritional status during their clinical course and also treatment response. A clearer identification of nutrition-related critical points during neoadjuvant treatment for gastric cancer is relevant to managing patient care and predicting clinical outcomes. The a...

CANCER ON THE ISLAND OF SÃO VICENTE, CAPE VERDE: AUDIT OF CANCER REGISTRY OF HO...

We describe the cases of cancer registered between 2018 and 2019 in the Oncological Registry of Hospital Dr. Baptist D’Souza. Sao Vicente Island, Cape Verde. There is also a critical assessment of its quality and an action plan. The five most registered types of cancer, in order of frequency, in the period (2018-2019) were: breast, prostate, oesophagus, cervix and stomach. We found that the oncological registra...