9 documents found, page 1 of 1

Sex and population differences underlie variation in reproductive success in a ...

Current rising temperatures are threatening biodiversity. It is therefore crucial to understand how climate change impacts on male and female fertility and whether evolutionary responses can help in coping with heat stress. We use experimental evolution to study male and female fertility during real-time evolution of two historically differentiated populations of Drosophila subobscura under different thermal se...

Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Po...

Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolut...

Comparison of Nasopharyngeal Samples for SARS‐CoV ‐2 Detection in a Paediatric ...

Aim: The diagnosis of coronavirus disease 2019 (COVID-19) depends on accurate and rapid testing. Choosing an appropriate sample may impact diagnosis. Naso-oropharyngeal swabs (NOS) are most frequently used, despite several limitations. Since studies suggest nasopharyngeal aspirate (NPA) as a superior alternative in children, we hypothesised collecting both nasopharyngeal swab and aspirate would improve our diag...

Evolutionary lessons from drosophila melanogaster for colonization : how do his...

Understanding the factors that constrain adaptation, namely in a colonization scenario, has been a major topic in evolutionary biology and was the chief focus of this thesis. Using a highly-replicated experimental evolution design with well-characterized Drosophila melanogaster populations, we aimed to respond to several evolutionary questions relevant for the colonization of a new habitat. First, we showed tha...

Different Genomic Changes Underlie Adaptive Evolution in Populations of Contras...

Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genome-wide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introd...

Oxidative stress profiles in brain point out a higher susceptibility of fish to...

This study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28 days of de...

Prevalência dos utentes com tempo de tromboplastina parcial activado baixo, na ...

Introdução: A doença tromboembolica venosa (TEV) constitui um problema de grande impacto na saúde pública pela sua morbilidade e mortalidade. Tem uma etiologia multifactorial e os factores de risco são aditivos. Segundo vários estudos publicados a determinação de um tempo de tromboplastina parcial activado (TTPa) baixo, associa-se per se a um risco au- mentado de TEV. Objectivo: Cálculo da prevalência dos valor...

Doenças Neuromusculares na Idade Pediátrica em Portugal - Estudo Preliminar

Synthesis, conformational behaviour, alkali and alkaline-earth metal cation ext...

1,3-Dimethoxy-p-tert-butyldihomooxacalix[4]arene-crown-6 (4) was synthesized for the first time. 4 was isolated in a partial cone A conformation in solution at room temperature, as established by NMR measurements (H-1, C-13, COSY and NOESY). Conformational behaviour of 4 and p-tert-butyldihomooxacalix[4]-crown-5 (2) and crown-6 (3) was studied by dynamic H-1 NMR and by MD/MM calculations. Two-phase (water/CH2Cl...