6 documents found, page 1 of 1
Childhood obesity, thyroid function, and insulin resistance – is there a link? ...
Santos, MI; Limbert, C; Marques, FC; Rosário, F; Lopes, LSerum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear. OBJECTIVES: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment - insulin resistance (HOMA-IR); and to verify whether TSH level...
Osteogénese imperfeita: experiência do Serviço de Ortopedia do Hospital Dona Es...
Escobar, C; Malveiro, D; Salgado, A; Santos, MI; Capagnolo, J; Neves, MIntrodução/Objectivos: A osteogénese imperfeita (OI) é uma doença genética caracterizada por fragilidade óssea e osteopenia. O tratamento implica uma abordagem multidisciplinar e tem como objectivo a melhoria da qualidade de vida. Os autores pretendem descrever as características de uma amostra de crianças com OI, avaliar o tratamento realizado e a evolução clínica pré e pós terapêutica. Material e Métodos: Est...
Description of an autosomal dominant form of Kabuki syndrome by mutation in MLL...
Santos, MI; Beleza-Meireles, A; Loureiro, S; Fonseca, M; Reis, CF; Rodrigues, F; Ramos, F; Ramos, L; Cardoso, E; Saraiva, JMAims: Although there are more than 400 cases of Kabuki syndrome described in the literature, it is believed that this syndrome is under-diagnosed. Most cases occur sporadically, despite cases with autosomal dominant familial transmission being described. Here we describe three cases identified in the same family. Cases description: A family (mother and two children) was diagnosed with Kabuki syndrome. The three...
Osteogénese Imperfeita – Experiência do Serviço de Ortopedia do Hospital Dona E...
Escobar, C; Malveiro, D; Salgado, A; Santos, MI; Campagnolo, J; Cassiano Neves, MIntrodução/Objectivos: A osteogénese imperfeita (OI) é uma doença genética caracterizada por fragilidade óssea e osteopenia. O tratamento implica uma abordagem multidisciplinar e tem como objectivo a melhoria da qualidade de vida. Os autores pretendem descrever as características de uma amostra de crianças com OI, avaliar o tratamento realizado e a evolução clínica pré e pós terapêutica. Material e Métodos: Est...
Improved synthesis of amino acid and dipeptide chloromethyl esters using bromoc...
Gomes, P; Santos, MI; Trigo, MJ; Castanheiro, R; Moreira, RPeptide chloromethyl esters are important compounds in prodrug synthesis. A simple, mild and efficient method for the synthesis of chloromethyl esters of N-blocked amino acids and dipeptides using exclusively bromochloromethane is reported. These N-blocked amino acid and dipeptide chloromethyl esters react readily with the carboxylic acid group of aspirin and with the sulfonamido group of the antimalarial sulfa...
Improved synthesis of amino acid and dipeptide chloromethyl esters using bromoc...
Gomes, P; Santos, MI; Trigo, MJ; Castanheiro, R; Moreira, RPeptide chloromethyl esters are important compounds in prodrug synthesis. A simple, mild and efficient method for the synthesis of chloromethyl esters of N-blocked amino acids and dipeptides using exclusively bromochloromethane is reported. These N-blocked amino acid and dipeptide chloromethyl esters react readily with the carboxylic acid group of aspirin and with the sulfonamido group of the antimalarial sulfa...