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Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic ...

Neves, AR; Luciana Gomes; Faria, SI; Sousa, J; Ruivo, R; Pascoa, I; Pinto, M; Emilia Sousa; Santos, MM; Silva, ER; Marta Correia da Silva

The development of harmless substances to replace biocide-based coatings used to prevent or manage marine biofouling and its unwanted consequences is urgent. The formation of biofilms on submerged marine surfaces is one of the first steps in the marine biofouling process, which facilitates the further settlement of macrofoulers. Anti-biofilm properties of a synthetic polyphenolic compound, with previously descr...


Synthesis and antibacterial activity of ionic liquids and organic salts based o...

Ferraz, R; Silva, D; Dias, AR; Dias, V; Santos, MM; Pinheiro, L; Prudêncio, C; Noronha, JP; Petrovski, Ž; Branco, LC

The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed ß-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the...


Disruption of zebrafish (Danio rerio) embryonic development after full life-cyc...

Soares, J; Coimbra, AM; Reis Henriques, MA; Monteiro, NM; Vieira, MN; Oliveira, JMA; Guedes Dias, P; Fontainhas Fernandes, A; Silva S Parra

Exposure of fish to the synthetic estrogen ethinylestradiol (EE(2)) has been shown to induce a large set of deleterious effects. In addition to the negative impact of EE2 in reproductive endpoints, concern has recently increased on the potential effects of EE2 in fish embryonic development. Therefore, the present study aimed at examining the effects of EE2 on the full embryonic development of zebrafish in order...


Medicinal Chemistry

Moreira, R; Carreiras, MC; Lopes, F; Rocha, MJP; Mendes, E; LConstantino, Dias,; Santos, MM; Lavrado, J; Capela, R; Santana, AB; Valente, E


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