3 documents found, page 1 of 1
O Carvedilol Protege Mitocôndrias Cardíacas Isquémicas de Lesões Induzidas Por ...
Carreira, R; Duarte, AI; Monteiro, P; Santos, MS; Rego, AC; Oliveira, CR; Gonçalves, L; Providência, LAIschemia negatively affects mitochondrial function by inducing the mitochondrial permeability transition (MPT). The MPT is triggered by oxidative stress, which occurs in mitochondria during ischemia as a result of diminished antioxidant defenses and increased reactive oxygen species production. It causes mitochondrial dysfunction and can ultimately lead to cell death. Therefore, drugs able to minimize mitochond...
Histological changes and impairment of liver mitochondrial bioenergetics after ...
Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, RThis study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measur...
Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African...
Bandelt, H-J; Alves-Silva, J; Guimarães, PEM; Santos, MS; Brehm, A; Pereira, L; Coppa, A; Larruga, JM; Rengo, C; Scozzari, R; Torroni, A; Prata, MJThe mtDNA haplogroup L3e, which is identified by the restriction site +2349 MboI within the Afro-Eurasian superhaplogroup L3 (-3592 HpaI), is omnipresent in Africa but virtually absent in Eurasia (except for neighbouring areas with limited genetic exchange). L3e was hitherto poorly characterised in terms of HVS-I motifs, as the ancestral HVS-I type of L3e cannot be distinguished from the putative HVS-I ancestor...