9 documents found, page 1 of 1

Inhibition of Streptococcus mutans biofilm accumulation and development of dent...

Made available in DSpace on 2020-12-10T16:31:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); USPHS Research grant from the National Institute of Dental and Craniofacial Research (National Institutes of Health, USA); Coordenação de Aperfeiçoamento de Pessoal de Nív...

Synergism of plant compound with traditional antimicrobials against Streptococc...

Mastitis is an inflammation of the mammary gland that causes major losses in the dairy industry. Streptococcus spp. are among the main agents of this disease. Increased resistance to antibiotics is one of the causes of therapeutic failure. Plants, due to their broad chemodiversity, are an interesting source of new molecules with antibacterial activity. Using these compounds along with traditional antibiotics is...

Design and synthesis of new Benzophenone derivatives with in vivo anti-inflamma...

A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...

Addition of pooled pumpkin seed to mixed meals reduced postprandial glycemia: a...

We investigated if pumpkin and flaxseeds could improve postprandial glycemic, food intake, and appetitive responses. Herein, we hypothesize based on the literature that pumpkin seed has potential to lower postprandial glycemic effects. Therefore, we conducted a randomized, single-blind, placebo-controlled, crossover design study involving normoglycemic adults (food intake: n = 25; glycemia: n = 15). Three high-...

Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabida...

Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate ...

Synthesis and in vitro evaluation of leishmanicidal activity of 7-hydroxy-4-phe...

Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against promastigote and amastigote forms of Leishmania amazonensis, as well their toxicity in murine macrophages. Compounds 4 and 7 showed the most significant results against promastigote forms of L. amazonensis. They were at least three-fold more active than 1 and ...

Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabida...

Made available in DSpace on 2018-11-26T16:16:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-05-01. Added 1 bitstream(s) on 2019-10-09T18:25:36Z : No. of bitstreams: 1 S0102-695X2015000300228.pdf: 675360 bytes, checksum: ed8bbb1454f9719acc059484c6f335cf (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Coordenação d...

The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallik...

The human tissue kallikreins (KLK1–KLK15) comprise a family of 15 serine peptidases detected in almost every tissue of the human body and that actively participate in many physiological and pathological events. Some kallikreins are involved in diseases for which no effective therapy is available, as for example, epithelial disorders, bacterial infections and in certain cancers metastatic processes. In recent ye...

Atividade antiinflamatória do composto natural 1,7-diidroxi-3,8-dimetoxixantona