14 documents found, page 1 of 2
Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesi...
Moreira, Maria Eliza de Castro; Araújo, Fernanda de Oliveira; Sousa, Andressa Rodrigues de; Toledo, Renata Celi Lopes; Benjamin, Laércio dos AnjosThe aim was to evaluate the effect of the ethanol extract of bacupari peel (EEB) on biometric measurements, hepatic lipogenesis and progression of non-alcoholic fatty liver disease (NAFLD) in obese Wistar rats. Chemical analysis of the bacupari peel extract identified 7-epiclusianone as the major constituent (140.02 mg/g) followed by morelloflavone (35.86 mg/g). Animals treated with high fat diet plus EEB (BHFD...
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone agai...
Aranda, Martha Isabel Realpe; Gómez, Gabriel Andres Tafur; Barros, Mariana de; Santos, Marcelo Henrique dos; Oliveira, Leandro Licursi deIn poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infections. However, the indiscriminate use of these agents provides favorable conditions for selecti...
Morphology, ultrastructure, and chemical compounds of the osmeterium of Heracli...
Martínez, Luis Carlos; Neves, Guilherme da Silva; Cossolin, Jamile Fernanda; Santos, Marcelo Henrique dos; Zanuncio, José Cola; Serrão, José EduardoThe osmeterium, found in papilionoid larvae, is an eversible organ with an exocrine gland that produces substances in response to the mechanical disturbances caused by natural enemies. The anatomy, histology and ultrastructure of the osmeterium, and the chemical composition of its secretion in Heraclides thoas (Lepidoptera: Papilionidae) were studied. Heraclides thoas larvae have a Y-shaped osmeterium in the th...
Evaluation of anxiolytic-like effect of 7-epiclusianone isolated from Garcinia ...
Veloso, Clarice de Carvalho; Silva, Mayara Bueno da; Megda, Marianne de Oliveira; Santos, Marcelo Henrique dos; Giusti-Paiva, AlexandreGarcinia brasiliensis Mart., Clusiaceae, species became the target of studies for some years because it has several compounds including polyprenylated benzophenones, as 7-epiclusianone. This benzophenone has several properties, such as leishmanicidal, anti-inflammatory and antinociceptive effects, however still did not be studied anxiolytic activity. For this, the open field and elevated plus maze tests were us...
Design and synthesis of new benzophenone derivatives with in vivo anti-inflamma...
Januário, Jaqueline Pereira; Souza, Thiago Belarmino de; Lavorato, Stefânia Neiva; Maiolini, Tatiane Cristina Silva; Domingos, Olívia da SilvaA series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...
Synthesis, activity and docking studies of eugenol-based glucosides as new agen...
Santos, Marcelo Henrique dos; Hipólito, Taciane Maíra Magalhães; Bastos, Guilherme Tadeu Lemos; Barbosa, Thúlio Wliandon LemosSeventeen new synthetic derivatives of eugenol (6, 8–15 and 8′‐15′) were planned following literature reports on antifungal activities of nitroeugenol and eugenol glucoside. The anti‐Candida activity of these compounds was investigated by in vitro assay and the cytotoxicity evaluation was performed with the most active compounds. The peracetylated glucosides presented better biological results than their hydrox...
Growth curve, biochemical profile and phytochemical analyses in calli obtained ...
Santos Filho, Plinio Rodrigues dos; Santos, Breno Régis; Barbosa, Sandro; Vieira, Letícia Rios; Freitas, Natália Chagas de; Dias, Daniele FerreiraGarcinia brasiliensis, popularly known as Bacupari, is native to the Amazon and commonly used in folk medicine for its therapeutic properties. This plant is rich in bioactive compounds like benzophenones. However, there are no works about the in vitro establishment and achievement of secondary metabolites in this plant. Thus, the aim of this work was to determine the growth curve and to perform the biochemical ...
Chemical variation in the essential oil of Hyptis suaveolens (L.) Poit., under ...
Barbosa, Luiz Cláudio de Almeida; Martins, Felipe Terra; Santos, Marcelo Henrique dos; Polo, MarceloThis study was performed to establish the correlation between the growth conditions and essential oil composition of Hyptis suaveolens from Alfenas (MG), Brazil. The plants were grown in a greenhouse, four treatments were used and they were harvested at two different periods of time (60 and 135-day-old plants). The essential oil composition was determined by GC-MS analysis. The terpenes spathulenol, globulol, d...
Antibacterial activity of 7-epiclusianone and Its novel copper metal complex on...
Barros, Mariana de; Perciano, Pedro Griffo; Santos, Marcelo Henrique dos; Oliveira, Leandro Licursi De; Costa, Éderson D’MartinMastitis is an inflammation of mammary gland parenchyma that adversely affects bovine health and dairy production worldwide despite significant efforts to eradicate it. The aim of this work was to characterize the antimicrobial activity of 7-epiclusianone (7-epi), a compound extracted from the Rheedia brasiliensis fruit, its complex with copper against Streptococcus spp. isolated from bovine mastitis, and to as...
Estudo químico dos frutos de Rheedia gardneriana (Pl. e Tr.) e aplicações bioló...
Santos, Marcelo Henrique dosCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; Rheedia gardneriana, conhecida popularmente como “bacuparí”, “bacuparí miúdo” e “bacoparé”, é uma planta da família Guttiferae, nativa da região Amazônica, e se encontra espalhada por todo o território brasileiro em menor proporção. O estudo químico do fruto (casca e polpa) conduziu à identificação dos seguintes constituintes: sesquiterpenos (mistura ...