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Tackling water contamination by oncologic drugs: supported ionic liquids as sus...

Francisco, Rafael; Monteiro, Bruna; Santos, Maria J.; Silva, Francisca A. e; Venâncio, Cátia; Neves, Márcia C.; Lopes, Isabel; Sousa, Ana C. A.

Due to the increasing incidence of cancer, the consumption of highly toxic oncological drugs is continuously growing. Given the current lack of efficient technologies to remove/treat these toxic drugs in wastewater treatment plants, the environmental quality is compromised, and aquatic organisms are at risk. To address this critical environmental burden, a new strategy based on supported ionic liquids (SILs) fo...


Factors influencing the relative abundance of invasive predators and omnivores ...

Lamelas-López, Lucas; Santos, Maria J.

Invasive alien species (IAS) are the major cause of native species extinctions on islands worldwide. To mitigate or eliminate IAS impacts, eradication is often the best alternative. However, IAS removal may result in cascading effects, through increase in prey abundance, mesopredator release, or competitor release. Our objective is to determine which ecological processes may influence the relative abundance of ...


Modelling the distribution of Mustela nivalis and M. putorius in the Azores arc...

Lamelas-López, Lucas; Pardavila, Xose; Borges, Paulo A. V.; Reis, Margarida Santos; Amorim, Isabel R.; Santos, Maria J.

The aims of this study were to predict the potential distribution of two introduced Mustelidae, Mustela nivalis and M. putorius in the Azores archipelago (Portugal), and evaluate the relative contribution of environmental factors from native and introduced ranges to predict species distribution ranges in oceanic islands. We developed two sets of Species Distribution Models using MaxEnt and distribution data fro...


IonCytDevice: removal of cytostatics from cancer patients’ urine using supporte...

Silva, Francisca A. e; Francisco, Rafael; Santos, Maria J.; Almeida, Catarina; Neves, Márcia C.; Sousa, Ana C. A.; Freire, Mara G.

Cancer prevalence is rising at a fast rate, registering 18.1 million new cancer cases in 2018. Aiming to provide better therapeutic options and to boost survivorship and life quality of cancer patients, the medical field contributed to significant progresses. Under this framework, the consumption of anticancer drugs, namely cytostatics, increased over the past years. However, urinary excretion of cystostatic dr...


Modelling the distribution of Mustela nivalis and M. putorius in the Azores arc...

Lamelas-López, Lucas; Pardavila, Xosé; Borges, P.A.V.; Santos-Reis, Margarida; Rosário, Isabel Amorim Do; Santos, Maria J.

The aims of this study were to predict the potential distribution of two introduced Mustelidae, Mustela nivalis and M. putorius in the Azores archipelago (Portugal), and evaluate the relative contribution of environmental factors from native and introduced ranges to predict species distribution ranges in oceanic islands. We developed two sets of Species Distribution Models using MaxEnt and distribution data fro...


Effectiveness and long-term retention of anti-tumour necrosis factor treatment ...

Mourao, Ana F.; Santos, Maria J.; Melo Gomes, Jose A.; Martins, Fernando M.; Mendonca, Silvia C.; Ramos, Filipa Oliveira; Fernandes, Susana

Methods. We prospectively collected patient and disease characteristics from patients with JIA who started biological therapy. Adverse events were collected during the follow-up period. Predictors of response at 1 year and drug retention rates were assessed at 4 years of treatment for the first biologic agent.Results. A total of 812 JIA patients [65% females, mean age at JIA onset 6.9 years (s.d. 4.7)], 227 rec...


Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Rela...

Costa, Nuno; Pires, Ana E.; Gabriel, Ana M.; Goulart, Luiz F.; Pereira, Clara; Leal, Bárbara; Queiros, Ana C.; Chaara, Wahiba; Moraes-Fontes, Maria F.

Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density.


Helminth parasites from the stomach of conger eel, Conger conger, from Madeira ...

Costa, Graça; Santos, Maria J.; Costa, Luísa; Biscoito, Manuel; Carvalho, Miguel Â. A. Pinheiro de; Moreira, Egberto Melo

Geographic variations in the diversity and prevalence of helminth parasites of fish can provide important clues as to the relatedness of fish populations. In the present work, the stomachs of 64 conger eels, Conger conger, collected during 1999 and 2000, were examined for the presence of parasites. Four fish were infected with L3 stages of the nematode Anisakis simplex s.l. (Anisakidae), 1 with the nematode Cri...


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