131 documents found, page 1 of 14
Recomendações sobre manipulação de anticorpos monoclonais em oncologia: propost...
Cardoso, Catarina; Henriques, Inês; Santos, Marlene; Moreira, FernandoEnquadramento: Existem diversas opções terapêuticas disponíveis para o tratamento do cancro, tais como a imunoterapia com recurso a anticorpos monoclonais (MAb) [1]. Por forma a garantir-se a correta manipulação dos MAb, reveste-se de particular importância a consulta de diretrizes e dos próprios resumos de características dos medicamentos (RCM). Uma diretriz consiste num conjunto de declarações, orientações ou...
Efeitos terapêuticos dos anticorpos monoclonais na doença de Alzheimer: protoco...
Reis , Joana; Moreira, Fernando; Santos, MarleneEnquadramento: A doença de Alzheimer é uma doença crónica neurodegenerativa, sendo a forma mais comum de demência [1]. Objetivo: Elaborar um protocolo metodológico que possibilite a identificação de ensaios clínicos sobre o uso terapêutico de anticorpos monoclonais na doença de Alzheimer. Métodos: Foram identificadas as principais bases de dados da área da saúde, seguindo-se a seleção de palavras-chave para pes...
Therapeutic drug monitoring education: The current state
Petrova, Guenka; Blagova, Stiliyana; Tachkov, Konstantin; Santos, Marlene; Bluett, James; Rumano, Merita; Kkolou, Elena; Drakalska, Elena; Arev, MarijaTo evaluate available information on therapeutic drug monitoring (TDM) education programmes and their implementation across different countries. The study was performed in two phases. First, a scoping review of scientific literature on available education programmes was performed. Afterwards, a questionnaire was distributed among a worldwide network of professionals engaged in the practice of TDM. Eight scienti...
Dose-dependent pharmacological mechanisms within the Neuroscience-based Nomencl...
Zemach, Sasson; Zohar, Joseph; Correll, Christoph U.; Stahl, Stephen M.; Drago, Filippo; Goodwin, Guy M.; Moller, Hans-Jurgen; Uchida, HiroyukiIn this Personal View, we introduce the concept of different dosage different pharmacology (DDDP), which describes how certain psychotropic medications have distinct therapeutic effects at low and high doses due to differing neurobiological mechanisms. Using the Neuroscience-based Nomenclature (NbN) framework, which classifies drugs by pharmacology and modes of action, we identified ten agents demonstrating DDD...
Genossensores Eletroquímicos de Identificação de Espécies Vegetais: Foco no Cas...
Morais, Stephanie; Pereira, Eduarda; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Deleure-Matos, Cristina; Barroso, FátimaNeste trabalho, foram desenvolvidos dois genossensores eletroquímicos descartáveis para a identificação de plantas baseado na reação de hibridização entre duas cadeias de ADN complementares de duas espécies de plantas: Erica arborea (urze) e Castanea sativa (castanheiro). Analisando bases de dados públicas, foram selecionados dois pares de sequências especificamente cortadas e desenhadas para identificar o ADN ...
Warfarin pharmacogenomics: Designing electrochemical DNA-based sensors to detec...
Barbosa, Tiago; Morais, Stephanie L.; Pereira, Eduarda; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Ferreira-Fernandes, Hygor; Pinto, GiovannyThe CYP2C9 enzyme is involved in the metabolism of warfarin. The CYP2C9 gene harbors several single-nucleotide polymorphisms (SNPs), including CYP2C9*2 (rs1799853), which is known to affect warfarin’s therapeutic response. So, it is important to develop analytical tools capable of genotyping these SNPs to adjust warfarin’s therapeutic outcomes. In this work, an electrochemical DNA-based sensor was constructed a...
Sources of bias when assessing seasonal Influenza vaccine performance: a narrat...
Martins, André Miguel; Juan, Luis Félix Valero; Santos, Marlene; Martins, João PauloThe best way to prevent influenza infection is through vaccination. Evaluating vaccine performance is essentially done through two types of study: clinical trials and the test negative design, an observational study derived from the case control. While in clinical trials the sources of bias are perfectly identified and there are specific tools for assessing them, in test negative design we find very varied sour...
Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towar...
Barbosa, Tiago; Morais, Stephanie L.; Carvalho, Renato; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Delerue-Matos, CristinaAnticoagulants, including warfarin, are often administered to patients who are exhibiting early symptoms of thromboembolic episodes or who have already experienced such episodes. However, warfarin has a limited therapeutic index and might cause bleeding and other clinical problems. Warfarin inhibits the vitamin K epoxide reductase complex subunit 1 (VKORC1), an enzyme essential for activating vitamin K, in the ...
Ensuring safety in cytotoxic drug preparation: A systematic review of guideline...
Moreira, Fernando; Jesus, Ângelo; Pinho, Cláudia; Santos, Marlene; Serdoura, Mélanie; Cruz, Agostinho; Moreira, Fernando; Jesus, Ângelo; Pinho, CláudiaChemotherapy preparation involves the use of specific techniques and equipment, given the need to maintain preparation sterility and its strict prescribed composition, and avoid occupational exposure to cytotoxic agents. This study aims to identify the most relevant contents for pharmacy professionals' education and training programs and to elucidate the evaluation procedure these professionals should follow wh...
Altered NRF2 signalling in systemic redox imbalance: Insights from non-communic...
Santos, Marlene; Morgenstern, Christina; Santos, MarleneThe balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions. Activated NRF2 regulates the expression of hundreds of genes containing antioxidant response elements (AREs) or electrophile response elements (EpRE) in their regulatory regions, often prom...