2 documents found, page 1 of 1
Development and validation of risk matrices for Crohn's Disease outcomes in pat...
Dias, Cláudia Camila; Rodrigues, Pedro Pereira; Coelho, Rosa; Santos, Paula Moura; Fernandes, Samuel; Lago, Paula; Caetano, Cidalina; Rodrigues, AngelaIntroduction: The establishment of prognostic models for Crohn's disease [CD] is highly desirable, as they have the potential to guide physicians in the decision-making process concerning therapeutic choices, thus improving patients' health and quality of life. Our aim was to derive models for disabling CD and reoperation based solely on clinical/demographic data. Methods: A multicentric and retrospectively enr...
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma ap...
Ferreira, Paula; Cravo, Marília; Guerreiro, Catarina Sousa; Tavares, Lourdes; Santos, Paula Moura; Brito, MiguelBackground & aims: Crohn’s disease (CD) is a multifactorial disease where resistance to apoptosis is one major defect. Also, dietary fat intake has been shown to modulate disease activity. We aimed to explore the interaction between four single nucleotide polymorphisms (SNPs) in apoptotic genes and dietary fat intake in modulating disease activity in CD patients. Methods: Polymerase Chain Reaction (PCR) and Res...