33 documents found, page 1 of 4
The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferat...
Santos, Paulo F.; Fazendeiro, Beatriz; Luca, Francis C.; Ambrósio, A. Francisco; Léger, HélèneNuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 protein kinases. LATS1 and 2 are core components of the well-studied Hippo pathway, which play a critical role in the regulation of cell proliferation, differentiation...
Bioactivity of the Geranium Genus: a Comprehensive Review
Graça, Vânia C.; Ferreira, Isabel C.F.R.; Santos, Paulo F.Background: Plants from the Geranium genus, which comprises about 400 species, have been used since ancient times in the practice of traditional medicines throughout the world. Therefore, herbal preparations based on Geranium species have found wide usage for the treatment of a variety of ailments. The aim of this work is to present a review, as comprehensive as possible, of the studies concerning different bio...
Echinacea purpurea (L.) moench: chemical characterization and bioactivity of it...
Coelho, Joana C.M.M.; Barros, Lillian; Dias, Maria Inês; Finimundy, Tiane C.; Amaral, Joana S.; Alves, Maria José; Calhelha, Ricardo C.Echinacea purpurea (L.) Moench is widely known for its medicinal properties, being one of the most used medicinal plants for its immunostimulant properties. Nevertheless, there is still scarce information on its cytotoxic activity. Thus, this study aims at evaluating the cytotoxicity and antimicrobial activity of several aqueous and organic extracts of the aerial parts of this plant and chemically characterizin...
Synthesis, photochemical and in vitro cytotoxic evaluation of new iodinated ami...
Mandim, Filipa; Graça, Vânia C.; Calhelha, Ricardo C.; Machado, Isabel Ferreira; Ferreira, Luis F.V.; Ferreira, Isabel C.F.R.; Santos, Paulo F.In this work, several benzothiazole-based aminosquaraine dyes, displaying strong absorption within the so-called phototherapeutic window (650–800 nm), were synthesized. The ability, of all the new dyes, to generate singlet oxygen was assessed by determining the correspondent phosphorescence emission and through the comparison with a standard. The quantum yields of singlet oxygen generation were determined and e...
Phenolic profile and effects of acetone fractions obtained from the inflorescen...
Mandim, Filipa; Barros, Lillian; Heleno, Sandrina A.; Pires, Tânia C.S.P.; Dias, Maria Inês; Alves, Maria José; Santos, Paulo F.The phenolic profile and the antibacterial activity against pathogenic commensal vaginal bacteria exhibited by different fractions of the acetone extract of heather was assessed. The acetone extract of Calluna vulgaris (L.) Hull was fractionated by silica gel column chromatography through an eluent system of increasing polarity, obtaining 10 different fractions (Fr 1 to Fr 10). The phenolic profile was analyzed...
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioact...
Mandim, Filipa; Barros, Lillian; Calhelha, Ricardo C.; Abreu, Rui M.V.; Pinela, José; Alves, Maria José; Heleno, Sandrina A.; Santos, Paulo F.The inflorescences of Calluna vulgaris were nutritionally and chemically characterized. Furthermore, different organic and aqueous extracts were prepared for the evaluation of their bioactive properties. From the obtained results, carbohydrates were the major compounds, followed by protein, lipid and ashes. It was possible to identify the sugars fructose and glucose, five organic acids, 26 individual fatty acid...
Isolation of secondary metabolites from Geranium molle L. with anticancer poten...
Graça, Vânia C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, Paulo F.Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against severa...
Atividade antibacteriana e efeito na microbiota vaginal de frações obtidas a pa...
Mandim, Filipa; Barros, Lillian; Heleno, Sandrina A.; Pires, Tânia C.S.; Dias, Maria Inês; Alves, Maria José; Santos, Paulo F.; Ferreira, Isabel C.F.R.A sociedade atual enfrenta uma preocupação crescente no que respeita à resistência microbiana aos antibióticos e, como consequência, a descoberta de novos agentes antimicrobianos eficazes torna-se uma prioridade global e urgente[1]. As matrizes naturais, devido à sua diversidade e riqueza em moléculas de reconhecida atividade biológica, têm sido extensivamente estudadas no sentido de avaliar também o seu potenc...
Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-b...
Magalhães, Álvaro F.; Graça, Vânia C.; Calhelha, Ricardo C.; Machado, Isabel Ferreira; Ferreira, L.F. Vieira; Ferreira, Isabel C.F.R.; Santos, Paulo F.Squaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic therapy. Several cationic aminosquaraine dyes bearing benzoselenazole terminal nuclei were synthezised and their cytotoxic activity was tested against four different human tumor cell lines – breast (MCF-7), non-small cell lung (NCI-H460), cervical (HeLa) and hepatocellular (HepG2) carcinomas – and ag...
Calluna vulgaris (L.) Hull: composição nutricional e caracterização do perfil f...
Mandim, Filipa; Barros, Lillian; Pereira, Eliana; Santos, Paulo F.; Ferreira, Isabel C.F.R.O aumento da qualidade de vida, através da adoção de um estilo de vida saudável e de boas práticas alimentares, tem cada vez mais importância na sociedade atual. O consumo de produtos de origem natural é cada vez mais procurado, contribuindo para que a caracterização e exploração destes produtos seja uma importante e ascendente área de investigação [1]. Calluna vulgaris (L.) Hull, vulgarmente conhecida por urze...