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The role of endoplasmic reticulum in amyloid precursor protein processing and t...
Plácido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; Cardoso, S.; Oliveira, C. R.The endoplasmic reticulum (ER) is the principal organelle responsible for the proper folding/processing of nascent proteins and perturbed ER function leads to a state known as ER stress. Mammalian cells try to overcome ER stress through a set of protein signaling pathways and transcription factors termed the unfolded protein response (UPR). However, under unresolvable ER stress conditions, the UPR is hyperactiv...
Date: 2014
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Origin: Estudo Geral - Universidade de Coimbra