5 documents found, page 1 of 1
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, PC; Soares, ML; Ferreira, AC; Santos, RF; Cavaleiro Rufo, J; Vasconcelos, D; Carvalho, A; Guimarães, S; Vasques-Nóvoa, F; Cardoso, C; Melo, NIntroduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood....
Physical Interactions With Bacteria and Protozoan Parasites Establish the Scave...
Cardoso, MS; Santos, RF; Almeida, S; Sá, M; Perez-Cabezas, B; Oliveira, L; Tavares, J; Carmo, AMSince the pioneering discoveries, by the Nobel laureates Jules Hoffmann and Bruce Beutler, that Toll and Toll-like receptors can sense pathogenic microorganisms and initiate, in vertebrates and invertebrates, innate immune responses against microbial infections, many other families of pattern recognition receptors (PRRs) have been described. One of such receptor clusters is composed by, if not all, at least sev...
Modulation of CD4 T cell function via CD6-targeting
Freitas, R; Basto, A; Almeida, S; Santos, RF; Gonçalves, CM; Corria-Osorio, J; Carvalho, T; Carmo, AM; Oliveira, V; Leon, K; Graca, LIn recent years molecules involved on the immune synapse became successful targets for therapeutic immune modulation. CD6 has been extensively studied, yet, results regarding CD6 biology have been controversial, in spite of the ubiquitous presence of this molecule on virtually all CD4 T cells. We investigated the outcome of murine and human antibodies targeting CD6 domain 1. We found that CD6-targeting had a ma...
CD6, a rheostat-type signalosome that tunes T cell activation
Gonçalves, CM; Henriques, SN; Santos, RF; Carmo, AMFollowing T cell receptor triggering, T cell activation is initiated and amplified by the assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate several signaling cascades. The potency of signaling is, however, modulated by various inhibitory components already at the onset of activation, long before co-inhibitory immune checkpoints are expressed to help terminating the respons...
Cortical maturation in fetuses referred for ‘isolated’ mild ventriculomegaly: a...
Miguelote, RF; Vides, B; Santos, RF; Palha, JA; Matias, A; Sousa, NOBJECTIVES: To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. METHODS: This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fissure (CF) and syl...