4 documents found, page 1 of 1
Potencial citotóxico da quinoxalina sintética, intitulada PACP 08A, na linhagem...
Santos, Renan da SilvaCancer is responsible for a significant and growing number of deaths worldwide and is the second cause of death of the world's population. Synthetics products have taken more space in the research and in the pharmaceutical industry due to less environmental damage and the cost and production time reduce. This study evaluated the cytotoxic effects of the quinoxaline entitled PACP 08A on the viability of tumor ce...
Natural products as new antimitotic compounds for anticancer drug development
Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant’Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo DamascenoCell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics....
Desenvolvimento de linhagens geneticamente modificadas por CRISPR/CAS9 na ident...
Santos, Renan da SilvaCancer is a disease of heterogeneous genetic and epigenetic aspects. Knowing the demand for more specific treatments to the molecular subtypes, different tools for identifying targets of anticancer agents are required. The discovery of genome-editing technologies has leveraged different lines of research, most recently the CRISPR/Cas9 system has further facilitated genetic manipulation. The use of the CRISPR/Ca...
Geometria enumerativa via invariantes de Gromov-Witten e mapas estáveis
Santos, Renan da SilvaIn this work, I present the Gromov-Witten theory, quantum cohomology and stable maps and use these tools to obtain some enumerative results. In particular, I proof the Kontsevich formula to projective rational plane curves of degree d. I do an introductory study of Mumford-Knudsen spaces and construct the Kontsevich spaces in order to define gromov-witten invariants. These are used to define the quantum cohomol...