126 documents found, page 1 of 13
Fetal exposure to phthalates and body mass index from infancy to adolescence. T...
Sol, CM; Delgado, G; Kannan, K; Jaddoe, VWV; Trasande, L; Santos, SPrenatal exposure to phthalates might influence the development of childhood obesity. Most previous studies used body mass index (BMI) at a specific age instead of BMI development, which might be a better indicator of later health. We aimed to assess the association of prenatal phthalate exposure with longitudinal BMI development from infancy to adolescence. Among 1,379 mother-child pairs from a population-base...
ffect of resistance exercise training on blood antioxidant capacity in rats und...
Anjos, J; Santos, S; Anjos, L; Aires, I; Garcias, I; Azevedo, C; Silva, M; Oliveira, PA; Faustino-Rocha, Ana I; Peixoto, FIntroduction: Doxorubicin (DOX) is an efficient chemotherapeutic drug used in the treatment of several types of cancer, such as breast cancer. DOX causes cardiotoxicity that leads to cardiac inflammation and remodeling as a result of oxidative stress and impaired mitochondrial function. Several studies observed a beneficial effect of exercise training on antioxidants, due to upregulation of the activity of some...
Resistance exercise in an animal model of mammary cancer treated with doxorubic...
Anjos, L; Santos, S; Anjos, J; Aires, I; Garcias, I; Azevedo, C; Moreira-Gonçlaves, M; Ferreira, R; Duarte, JA; Oliveira, PA; Faustino-Rocha, Ana IIntroduction: Doxorubicin (DOX) is one of the most effective antitumor drugs for breast cancer treatment. DOX is associated to high toxicity in multiple organs and tissues. This study aimed to assess the effects of resistance exercise training (RET) in the hematological parameters of rats with mammary cancer treated with DOX. Material & Methods: Wistar Rats were divided into six groups: I (sedentary, SED), II (...
Urban environment during pregnancy and lung function, wheezing, and asthma in s...
Abellan, A; Warembourg, C; Mensink-Bout, SM; Ambros, A; de Castro, M; Fossati, S; Guxens, M; Jaddoe, VW; Nieuwenhuijsen, MJ; Vrijheid, M; Santos, SThe urban environment during pregnancy may influence child's respiratory health, but scarce evidence exists on systematic evaluation of multiple urban exposures (e.g., air pollution, natural spaces, noise, built environment) on children's lung function, wheezing, and asthma development. We aimed to examine the association of the urban environment during pregnancy with lung function, preschool wheezing, and scho...
Maternal hemoglobin and iron status in early pregnancy and childhood cardiac ou...
Quezada-Pinedo, HG; Jaddoe, V; Gaillard, R; Duijts, L; van Rijn, B; Reiss, IKM; Vermeulen, MJ; Santos, SBackground & aims: Dysregulation of iron homeostasis is associated with cardiac alterations in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy has long-term impact on cardiovascular health, and if this association is influenced by sex. Therefore, this study aimed to evaluate sex-specific association between maternal iron status during early pregnancy and cardiac outcomes in ...
Longitudinal associations of air pollution and green space with cardiometabolic...
Liu, M; Vaartjes, I; Hoek, G; Jaddoe, VWV; Santos, S; Schreuder, A; Vrijkotte, TGM; Grobbee, DE; Timmermans, EJBackground: This study examines longitudinal associations of air pollution and green space with cardiometabolic risk among children in the Netherlands. Methods: Three Dutch prospective cohorts with a total of 13,822 participants aged 5 to 17 years were included: (1) the Amsterdam Born Children and their Development (ABCD) study from Amsterdam (n = 2,547), (2) the Generation R study from Rotterdam (n = 5,431), a...
Enhancing tuberculosis surveillance in quarry workers: identifying vulnerable s...
Sousa, S; Carvalho, C; Alves, CM; Santos, S; Gonçalves, G; Duarte, RBackground: Stone quarry workers and others exposed to silica are especially vulnerable to tuberculosis (TB). Silicosis is a known risk factor for TB disease, but other common comorbidities and habits such as diabetes and alcohol and tobacco consumption may increase risk. We aimed to estimate the risk of TB infection among stone quarry workers and to identify associated factors. Methods: An annual TB infection ...
Is it worth screening quarry workers for TB infection in high-incidence areas? ...
Sousa, S; Carvalho, C; Santos, S; Alves, CM; Gonçalves, G; Almeida, Á; Duarte, RBackground: Tuberculosis (TB) infection screening of high-risk groups is an important strategy for achieving End TB targets. A TB infection screening program was implemented for quarry workers from a Portuguese high-incidence area in 2018–2022. We aimed to calculate the cost-benefit of the screening program from the societal perspective. Methods: We calculated medical and non-medical direct and indirect screeni...
Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes:...
Fernandes, A; Avraam, D; Cadman, T; Dadvand, P; Guxens, M; Binter, A-C; Pinot de Moira, A; Nieuwenhuijsen, M; Duijts, L; Julvez, J; De Castro, MStudies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European bi...
Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Ea...
Gonçalves Soares, A; Santos, S; Seyve, E; Nedelec, R; Puhakka, S; Eloranta, A-M; Mikkonen, S; Yuan, WL; Lawlor, DA; Heron, J; Vrijheid, M; Lepeule, JBackground: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (S...