7 documents found, page 1 of 1
Decellularized placental sponge: a platform for coculture of mesenchymal stem c...
Khosrowpour, Zhara; Hashemi, Seyed Mahmoud; Mohammadi-Yeganeh, Samira; Simorgh, Sara; Eftekhari, Behnaz Sadat; Milan, Peiman Brouki; Kundu, Subhas CEffective communication between immune and bone-forming cells is crucial for the successful healing of bone defects. This study aimed to assess the potential of a decellularized placental sponge (DPS) as a coculture system for inducing M1/M2 polarization in macrophages and promoting osteogenic differentiation in adipose-derived mesenchymal stem cells (AD-MSCs), both in vitro and in vivo. We prepared the DPS ...
Fabrication of a tissue engineering mat by emulsion-based electrospinning of po...
Alizadeh, Sanaz; Pezeshki-Modaress, Mohamad; Kundu, Subhas C; Gholipourmalekabadi, Mazaher; Samadikuchaksaraei, AliThe development of electrospun tissue engineering scaffolds using silk fibroin and polycaprolactone (PCL) has been reported. The challenge in this system is the design of a suitable solvent with high stability. In this study, a mat was electrospun with PCL-fibroin fibers using an emulsion consisting of PCL and a blend of fibroin and polyethylene oxide (PEO). The effects of different concentrations of fibroin an...
Synergetic dual antibiotics-loaded chitosan/poly (vinyl alcohol) nanofibers wit...
Alizadeh, Sanaz; Farshi, Paniz; Farahmandian, Navid; Ahovan, Zahra Aliakbar; Hashemi, Ali; Majidi, Mohammad; Azadbakht, AbdolnaserResistance of bacterial pathogens to conventional antibiotics has remained a significant challenge in managing post-wound infections, especially in developing countries. Here, a nanofibrous chitosan/poly (vinyl alcohol) (CS/PVA) mat was designed for controlled delivery of three different concentrations of two antibiotics (colistin/meropenem ratio of 32/64 μg/ml (AB1), 64/128 μg/ml (AB2), and 128/256 (AB3) μg/ml...
3D-printed placental-derived bioinks for skin tissue regeneration with improved...
Bashiri, Zahra; Fomeshi, Motahareh Rajabi; Hamidabadi, Hatef Ghasemi; Jafari, Davod; Alizadeh, Sanaz; Bojnordi, Maryam Nazm; Orive, GorkaExtracellular matrix (ECM)-based bioinks has attracted much attention in recent years for 3D printing of native-like tissue constructs. Due to organ unavailability, human placental ECM can be an alternative source for the construction of 3D print composite scaffolds for the treatment of deep wounds. In this study, we use different concentrations (1.5%, 3% and 5%w/v) of ECM derived from the placenta, sodium-algi...
Antibacterial smart hydrogels: new hope for infectious wound management
Ahovan, Zahra Aliakbar; Esmaeili, Zahra; Eftekhari, Behnaz Sadat; Khosravimelal, Sadjad; Alehosseini, Morteza; Orive, Gorka; Dolatshahi-Pirouz, AlirezaMillions of people die annually due to uncured wound infections. Healthcare systems incur high costs to treat wound infections. Tt is predicted to become more challenging due to the rise of multidrug-resistant conditions. During the last decades, smart antibacterial hydrogels could attract attention as a promising solution, especially for skin wound infections. These antibacterial hydrogels are termed â smartâ ...
Long-term preservation effects on biological properties of acellular placental ...
Asgari, Fatemeh; Khosravimelal, Sadjad; Koruji, Morteza; Ahovan, Zahra Aliakbar; Shirani, Ali; Hashem, Ali; Hamidabadi, Hatef GhasemiDecellularization, preservation protocol and storage time influence the biomechanical and biological properties of allografts and xenografts. Here, we examined the consequences of storage time on the antibacterial, angiogenic and biocompatibility properties of the decellularized placental sponge (DPS) in vitro and in vivo. The DPS samples were preserved for one, three and six months at −20 °C. The decellularize...
Silk fibroin/amniotic membrane 3D bi-layered artificial skin
Gholipourmalekabadi, Mazaher; Samadikuchaksaraei, Ali; Seifalian, Alexander M.; Urbanska, Aleksandra M.; Ghanbarian, Hossein; Hardy, John G.Burn injuries have been reported to be an important cause of morbidity and mortality and they are still considered as unmet clinical need. Although there is a myriad of effective stem cells that have been suggested for skin regeneration, there is no one ideal scaffold. The aim of this study was to develop a three-dimensional (3D) bi-layer scaffold made of biological decellularized human amniotic membrane (AM) w...