10 documents found, page 1 of 1

Effect of resistance exercise training on blood antioxidant capacity in rats un...

Introduction: Doxorubicin (DOX) is an efficient chemotherapeutic drug used in the treatment of several types of cancer, such as breast cancer. DOX causes cardiotoxicity that leads to cardiac inflammation and remodeling as a result of oxidative stress and impaired mitochondrial function. Several studies observed a beneficial effect of exercise training on antioxidants, due to upregulation of the activity of some...

Resistance exercise in an animal model of mammary cancer treated with doxorubic...

Introduction: Doxorubicin (DOX) is one of the most effective antitumor drugs for breast cancer treatment. DOX is associated to high toxicity in multiple organs and tissues. This study aimed to assess the effects of resistance exercise training (RET) in the hematological parameters of rats with mammary cancer treated with DOX. Material & Methods: Wistar Rats were divided into six groups: I (sedentary, SED), II (...

Biocompatibility of Platinum Nanoparticles in Brain ex vivo Models in Physiolog...

Platinum nanoparticles (PtNPs) have unique physico-chemical properties that led to their use in many branches of medicine. Recently, PtNPs gathered growing interest as delivery vectors for drugs, biosensors and as surface coating on chronically implanted biomedical devices for improving electrochemical properties. However, there are contradictory statements about their biocompatibility and impact on target orga...

Tissue response to neural implants: the use of model systems towards new design...

Tissue response to neural implants: The use of model systems toward new design ...

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of d...

Tissue response to neural implants: the use of model systems towards new design...

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design ...

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of d...

PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...

Delivering siRNA with dendrimers: In vivo applications

Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to treat or prevent several diseases. Among the explored strategies, the short-term silencing of protein coding genes mediated by siRNAs has a good therapeutic potential in a clinical setting. However, the widespread use of siRNA will require the development of clinically suitable, safe and effective vehicles with the ability t...

Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Heade...

Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, well-defined, highly branched and controllable structure, nanosize-scale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its inf...