6 documents found, page 1 of 1
Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease
Pereira, Raquel L.; Oliveira, Daniela; Pêgo, Ana P.; Santos, Sofia D.; Moreira, Felismina T.C.Alzheimer's disease (AD) is the most common dementia type and a leading cause of death and disability in the elderly. Diagnosis is expensive and invasive, urging the development of new, affordable, and less invasive diagnostic tools. The identification of changes in the expression of non-coding RNAs prompts the development of diagnostic tools to detect disease-specific blood biomarkers. Building on this idea, t...
Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease
Pereira, Raquel L.; Oliveira, Daniela; Pêgo, Ana P.; Santos, Sofia D.; Moreira, Felismina T.C.Alzheimer's disease (AD) is the most common dementia type and a leading cause of death and disability in the elderly. Diagnosis is expensive and invasive, urging the development of new, affordable, and less invasive diagnostic tools. The identification of changes in the expression of non-coding RNAs prompts the development of diagnostic tools to detect disease-specific blood biomarkers. Building on this idea, t...
Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease
Pereira, Raquel L.; Oliveira, Daniela; Pêgo, Ana P.; Santos, Sofia D.; Moreira, Felismina T. C.Alzheimer's disease (AD) is the most common dementia type and a leading cause of death and disability in the elderly. Diagnosis is expensive and invasive, urging the development of new, affordable, and less invasive diagnostic tools. The identification of changes in the expression of non-coding RNAs prompts the development of diagnostic tools to detect disease-specific blood biomarkers. Building on this idea, t...
Supramolecular presentation of bioinstructive peptides on soft multilayered nan...
Lopes, Maria; Torrado, Marília; Barth, Daryl; Santos, Sofia D.; Sever-Bahcekapili, Melike; Tekinay, Ayse B.; Guler, Mustafa O.; Cleymand, FranckPeptide amphiphiles (PAs) have emerged as effective molecular building blocks for creating self-assembling nanobiomaterials for multiple biomedical applications. Herein, we report a straightforward approach to assemble soft bioinstructive platforms to recreate the native neural extracellular matrix (ECM) aiming for neuronal regeneration based on the electrostatic-driven supramolecular presentation of laminin-de...
PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...
Santos, Sofia D.; Xavier, Miguel; Leite, Diana M.; Moreira, Débora A.; Custódio, Beatriz; Torrado, Marília; Castro, Rita; Leiro, VictoriaDrug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...
Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1...
Rosa, Alexandra I.; Grade, Sofia; Santos, Sofia D.; Bernardino, Liliana; Chen, Thomas C.; Relvas, João; Hofman, Florence M.; Agasse, FabienneNeurogenesis in the subventricular zone (SVZ) is regulated by diffusible factors and cell-cell contacts. In vivo, SVZ stem cells are associated with the abluminal surface of blood vessels and such interactions are thought to regulate their neurogenic capacity. SVZ neural stem cells (NSCs) have been described to contact endothelial-derived laminin via α6β1 integrin. To elucidate whether heterocellular contacts w...