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Vaccination with a CD4+ and CD8+ T-cell epitopes-based recombinant chimeric pro...
Mendes, Tiago A. O.; Dias, Daniel S.; Ribeiro, Patrícia A. F.; Martins, Vívian T.; Lage, Daniela P.; Costa, Lourena E.; Chávez-Fumagalli, Miguel A.Vaccination seems to be the best approach to control visceral leishmaniasis (VL). Resistance against infection is based on the development of a Th1 immune response characterized by the production of interferons-γ (IFN-γ), interleukin-12 (IL-12), granulocyte-macrophage-colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α), among others. A number of antigens have been tested as potential targets...
Date: 2018
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Origin: Oasisbr