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Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individua...
Nobrega, Claudia; Horta, Ana Maria Lacerda Morgado Fernandes Carvalho Aboim; Teixeira, Vítor Emanuel Coutinho; Martins-Ribeiro, AnaObjectives: A sizeable percentage of individuals infected by HIV and on antiretroviral therapy (ART) fail to increase their CD4+ T-cells to satisfactory levels. The percentage of regulatory T-cells (Tregs) has been suggested to contribute to this impairment. This study aimed to address this question and to expand the analysis of Tregs subpopulations during ART. Design: Longitudinal follow-up of 81 HIV-infected ...
Poor immune reconstitution in HIV-infected patients associates with high percen...
Horta, Ana; Nóbrega, Cláudia; Machado, Pedro Amorim; Teixeira, Vítor Emanuel Coutinho; Silva, Palmira Conceição Araújo Barreira; Boavida, SusanaCD4(+) regulatory T cells (Tregs) are essential for the maintenance of the immune system's equilibrium, by dampening the activation of potential auto-reactive T cells and avoiding excessive immune activation. To correctly perform their function, Tregs must be maintained at the right proportion with respect to effector T cells. Since this equilibrium is frequently disrupted in individuals infected with the human...
Thymic activity and regulatory CD4+ T cells in the immune reconstitution of HIV...
Teixeira, Vítor Emanuel CoutinhoThe Human Immunodeficiency Virus (HIV) infection is a major health problem worldwide estimated to affect about 34 million people. The hallmark of HIV pathogenesis is the gradual loss of the CD4+ T cell compartment along with a chronic state of immune hyperactivation. As infection progresses, HIV weakens the immune system to a level of profound immune dysfunction, which leads to the onset of Acquired Immunodefic...