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Elevated Pressure Changes the Purinergic System of Microglial Cells
Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana R.; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the pathophysiology of this disease. Although global changes of the purinergic system have been reporte...
Date: 2018
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Origin: Estudo Geral - Universidade de Coimbra