7 documents found, page 1 of 1

A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis

Abstract: Drug-induced liver injury is hardly diagnosed, considering not only the wide range of hepatotoxic substances but also the diversity of associated phenotypes and the absence of specific biomarkers. Symptom chronology, drug or toxic exposure, and temporal association help to establish the diagnosis. Exposure to isopropanol has known but rare toxic effects. We report the clinical case of a 33-year-old fe...

A Rare Case of Drug Induced Liver Injury Secondary to Empagliflozin

Abstract Drug induced liver injury (DILI) is a condition with a wide clinical spectrum. The diagnosis represents a challenge not only due to the large number of known hepatotoxic products but especially when the substance involved is not known to induce liver damage. Empagliflozin is linked to several adverse effects but has not been convincingly associated to DILI. We report a case of a 70-year-old type 2 diab...

A Case of Severe Cholestasis due to Hepatic AL Amyloidosis

Introduction: Immunoglobulin light chain-associated amyloidosis results from extracellular tissue deposition of fibrilforming monoclonal immunoglobulin light chains, secreted by a clone of plasma cells. Although the liver is often involved histologically, most cases are clinically asymptomatic, and severe intrahepatic cholestasis as the primary manifestation of the disease is rare. Clinical Case: We report an u...

Hiperplasia nodular focal múltipla: desafio diagnóstico

Hepatite autoimune: os critérios simplificados são menos sensíveis?

Introdução: A hepatite autoimune (HAI) tem apresentação clínica variável e o seu reconhecimento pode ser difícil. Os critérios de diagnóstico do Grupo Internacional de HAI, inicialmente propostos com fins científicos, são complexos na prática clínica. Em 2008, Henes et al. Propuseram critérios de diagnóstico simplificados (CDS), com valores preditivos positivos e negativos na ordem dos 90%, mas necessitando de ...

Permeabilidade Intestinal em Doentes com Cirrose Hepática: Alguns Factos, Muita...

Tuberculose miliar e febre Q em doente imunocompetente

A tuberculose miliar é a forma de doença progressiva resultante da disseminação hematogénea maciça do Mycobacterium tuberculosis (MT). Afecta imunodeprimidos e idosos e tem manifestações clínicas insidiosas e inespecíficas. O caso clínico descrito refere-se a um homem adulto, sem imunodeficiência, com infecção simultânea por Coxiella burnetti e MT. A raridade desta associação e a sua forma de apresentação subli...