Abstract Pregnancy requires several physiological adaptations from the maternal organism, including modifications in the glomerular filtration rate and renal excretion of several products. Chronic kidney disease (CKD) can negatively affect these modifications and consequently is associated with several adverse maternal and fetal adverse outcomes (gestational hypertension, progression of renal disease, pre-eclam...
Abstract Encapsulating peritoneal sclerosis is an uncommon but serious complication of peritoneal dialysis. In most cases, the symptoms appear after peritoneal dialysis withdrawal, which hampers its diagnosis. We present the case of a 44-years-old Caucasian male who had been on peritoneal dialysis for 6 years and 3 months and was switched to hemodialysis due to ultrafiltration failure. During his last months on...
ABSTRACT Coronavirus disease 2019 (COVID-19) has affected millions worldwide, and in particular the care of patients on maintenance hemodialysis. These patients are thought to be at high risk of severe SARS-CoV-2 infection due to their older age and multiple comorbidities. The aim of this study was to compare hemodialysis and non-dialysis COVID-19 patients and find possible risk factors for mortality in hemodia...
Sarcoidosis is a rare multisystem disease that is characterized by the formation of inflammatory granulomatous processes. The lung is the most frequently affected organ, but kidney injury can also occur. It is a disease with a highly variable course and prognosis and non-consensual treatment. This report describes the successful case of a patient with sarcoidosis presenting with pulmonary, cutaneous and renal i...
Atheroembolic renal disease is a multisystem clinical entity of unknown incidence. It is often associated with severe atherosclerotic disease and its etiology can be spontaneous or iatrogenic. Its pathophysiology is based on renal dysfunction secondary to embolization of cholesterol crystals, followed by occlusive phenomena affecting the renal vasculature. The present report describes the case of a patient with...
A nefrite intersticial aguda é uma causa comum de lesão renal aguda induzida na maioria dos casos por exposição a fármacos. Pode também ter etiologia autoimune, infiltrativa ou infeciosa. Numa pequena percentagem de doentes com nefrite intersticial aguda (5-10%) ocorre associação com uveíte definindo, assim, a síndrome nefrite túbulo-intersticial aguda e uveíte (TINU). Os autores apresentam um caso clínico de n...
Background: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according ...
Objective: To determine risk factors for acute rejection in the first 6 months post- transplant and their effect on death-censored graft and patient survival in the 990-1999 and 2000-2009 periods. Patients and Methods: Retrospective analysis of acute rejection episodes was performed separately in two periods: 1990-1999 and 2000-2009. Multivariate logistic regression analysis was performed in order to identify r...
Introduction: Simultaneous pancreas-kidney transplantation (SPKT) outcomes are conditioned in the short-term mostly by post-operative complications. In the long-term, cardiovascular (CV) disease and immunological loss are the main limitations to transplant survival. Aims: To analyse retrospectively the results from 150 SPKT performed at our centre. Patients and Methods: The 81 females and 69 males had a mean ag...
Introduction: Multiple myeloma is a plasma cell dyscrasia that accounts for almost 10% of all haematologic malignancies. It often presents with acute kidney injury that has long been associated with a poor prognosis. It is important to recognize markers of poor prognosis to promote an early and aggressive management of the disease, to improve disease outcomes. Subjects and Methods: We have, therefore, investiga...