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Association of oxidative stress and DNA damage with grafting time in patients w...
Santos,Thayna Nogueira dos; Duarte,Fernando Barroso; Maia Filho,Pedro Aurio; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza CavalcanteABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were per...
Tumor suppressor p53 protein expression: prognostic significance in patients wi...
Duarte,Fernando Barroso; Gonçalves,Romelia Pinheiro; Barbosa,Maritza Cavalcante; Rocha Filho,Francisco Dário; Santos,Talyta Ellen de Jesus dosBACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.OBJECTIVE: To evaluate ...
Methemoglobin measure in adult patients with sickle-cell anemia: influence of h...
Laurentino,Marilia Rocha; Carvalho,Teresa Maria de Jesus Ponte; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza Cavalcante; Santos,Thayna Nogueira dosIntroduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) therapy on this marker in patients with SCA. Materials and methods: Blood samples from 53 patients with SCA at the steady-state, with and without HU therapy, and 30 h...