4 documents found, page 1 of 1
Recentes avanços na funcionalização seletiva de quinolinas
Ferreira,Dartagnan S. P.; Murie,Valter E.; Santos,Thiago dos; Vieira,Paulo C.; Clososki,Giuliano C.Heterocyclic compounds form an important and extensive group of organic substances. Among nitrogenous heterocyclic molecules, quinolines stand out for exhibiting attractive chemical and biological properties. These substances can be used as ligands, sensors, luminescent and agrochemical materials. In addition, quinoline-containing compounds can exhibit a wide spectrum of pharmacological properties, allowing the...
Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vit...
Clososki,Giuliano C.; Soldi,Rafael A.; Silva,Rodrigo M. da; Guaratini,Thais; Lopes,José N. C.; Pereira,Pâmela R. R.; Lopes,João L. C.; Santos,Thiago dosThe recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem. In this sense, repositioning of antiretrovirals has captured the attention of the scientific community. Tenofovir disoproxil fumarate (TDF) is an antiretroviral compound that is used to treat acquired immune deficiency syndrome (AIDS) and hepatitis B. In this short r...
Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3- Triazoles as ...
Santos,Thiago dos; Coelho,Camila M.; Elias,Thiago C.; Siqueira,Fallon S.; Nora,Eloísa S. S. D.; Campos,Marli M. A. de; Souza,Gabriel A. P. deEugenol has diverse biological properties including antimycobacterial activity, and the triazole ring is an important heterocycle in antimycobacterial compounds. Therefore, this research aimed to synthesize novel eugenol-derived 1,2,3-triazole as antimycobacterial agents with interesting cytotoxic profile and pharmacological assets. Sixteen compounds were obtained and characterized by nuclear magnetic resonance...
Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Nove...
Coelho,Camila M.; Santos,Thiago dos; Freitas,Poliany G.; Nunes,Juliana B.; Marques,Marcos J.; Padovani,Camila G. D.; Júdice,Wagner A. S.; Camps,IhosvanyLeishmaniasis is a neglected pathology with a high incidence worldwide, and is a governmental health issue due to the increased morbidity and mortality associated with the disease and a scarce therapeutic arsenal. Cysteine proteases have been investigated as targets for new drugs because they are essential in the infectivity of the parasite during its interaction with the host and in its nutrition. This study a...