8 documents found, page 1 of 1
Dynamics of Soluble Factors and Double-Negative T Cells Associated with Respons...
Silva, Joana Delgado; Rodrigues-Santos, Paulo; Almeida, Jani Sofia; Santos Rosa, Manuel; Gonçalves, LinoThe role of the immune system, and hence inflammation, in the pathophysiology of hypertensive patients is not clear. Until now, most clinical and biochemical parameters have failed to predict a positive response to renal denervation (RDN). Our aim was to evaluate the immune response in a cohort of patients treated by RDN, through the analysis of cytokine, chemokine, and growth factor behavior. A population of 2...
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Imm...
Sousa, Luana Madalena; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Santos Rosa, Manuel; Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, PauloSoft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-a...
Immune Responses after Vascular Photodynamic Therapy with Redaporfin
Lobo, Ana Catarina S.; Silva, Lígia C. Gomes da; Rodrigues-Santos, Paulo; Cabrita, António; Santos Rosa, Manuel; Arnaut, Luís G.Photodynamic therapy (PDT) relies on the administration of a photosensitizer (PS) that is activated, after a certain drug-to-light interval (DLI), by the irradiation of the target tumour with light of a specific wavelength absorbed by the PS. Typically, low light doses are insufficient to eradicate solid tumours and high fluence rates have been described as poorly immunogenic. However, previous work with mice b...
NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Ty...
Almeida, Jani Sofia; Couceiro, Patrícia; López-Sejas, Nelson; Alves, Vera; Růžičková, Lenka; Tarazona, Raquel; Solana, Rafael; Tavares, PauloTherapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the ro...
Populações Celulares Periféricas (CD4+, CD8+ e CD19+) em Indivíduos Dislipidémicos
Pereira de Moura, José; Santos Rosa, Manuel; Alves, Vera; Mota-Pinto, Anabela; Rodrigues, Vítor; Silva, José Manuel; Moura, J. J. Alves deIntrodução: Os mecanismos imunológicos e inflamatórios têm um papel crucial no desenvolvimento da aterosclerose e na sua tradução clínica. São inúmeros os estudos que procuraram relacionar os mais diversos marcadores inflamatórios – leucócitos, proteína C reactiva, interleucinas, quimiocinas, moléculas de adesão, metaloproteinases, etc – com os factores de risco clássicos da aterosclerose, a formação da placa e...
CD4+, CD8+ AND CD19+ Cells at Individuals with Dyslipidemia
Pereira de Moura, Jose; Santos Rosa, Manuel; Alves, Vera; Mota Pinto, Anabela; Rodrigues, Victor; Silva, José Manuel; Alves de Moura, J. J.Introduction: The past decade has witnessed an increasing recognition that inflammatory mechanisms play a central role in the pathogenesis of atherosclerosis and its complications. Recently, attention was focused on the potential role of plasma markers of inflammation as risk predictors among those at risk for cardiovascular events. Of these potential markers, C-reactive protein (CRP), IL6, metalloproteinases, ...
Immunological parameters in burns
Cardoso, Susana; Cabral, Luis; Cruzeiro, Celso; Garção, Fátima; Santos Rosa, ManuelIntroduction: The activation of a pro-inflammatory cascade induced by burn injury seems to be an important mechanism in the development of sepsis and multiple organ failure. Most studies refer to a deregulation of macrophages activity and changes of cytokines Th1/Th2. However, there is no pattern evolution for the various situations. Methods: For this preliminary and exploratory prospective study, we intend to ...
Parâmetros imunológicos de biocompatibilidade de membranas de diálise
Sá, Helena; Mota-Pinto, Anabela; Anjos, Maria João; Gomes, Henrique; Campos, Mário; Santos Rosa, ManuelA biocompatibilidade de um material artificial é tanto maior quanto menos a sua capacidade de desencadear a activação de sistemas celulares e humorais quando posto em contacto com o organismo vivo. O estudo da biocompatibilidade em relação com a hemodiálise é de particular relevância clínica, já que se trata de uma situação em que, de forma repetitiva, ocorre exposição do sangue a um material não biológico (mem...