8 documents found, page 1 of 1

Coreceptor Usage by HIV-1 and HIV-2 Primary Isolates: The Relevance of CCR8 Che...

The human immunodeficiency virus replication cycle begins by sequential interactions between viral envelope glycoproteins with CD4 molecule and a member of the seven-transmembrane, G-protein-coupled, receptors' family (coreceptor). In this report we focused on the contribution of CCR8 as alternative coreceptor for HIV-1 and HIV-2 isolates. We found that this coreceptor was efficiently used not only by HIV-2 but...

Caracterização molecular do gene env de estirpes primárias VIH-2 CCR5/CXCR4 ind...

Chemokine receptors and its importance in the replication cycle of human immuno...

Human immunodeficiency virus (HIV) infection of host cells begins with binding of viral envelope (Env) surface (SU) glycoprotein to specific receptors present at plasma cell membrane. One of these receptors is the CD4 molecule which can be found namely in T-helper lymphocytes (T-CD4+), macrophages and dendritic cells. Binding of SU glycoprotein to CD4 molecule, enables HIV to adsorb to target cell membrane and ...

HIV-2 infection and chemokine receptors usage - Clues to reduced virulence of H...

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are the causative agents of Acquired Immunodeficiency Syndrome (AIDS). Without therapeutic intervention, HIV-1 or HIV-2 infections in humans are characterized by a gradual and irreversible imm

Functional characterization of the gp105 of primary HIV-2 strains unable to use...

Construction and characterization of CD4-independent infectious recombinant HIV...

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) differ in their pathogenic mechanisms as evidenced by lower rate of disease progression. lower transmission rates and lower viral load in peripheral blood for HIV-2. One of the many factors th

Identification and characterization of HIV-2 strains obtained from asymptomatic...

In vivo, human immunodeficiency virus type 2 (HIV-2) infection reveals several unique characteristics when compared to HIV-1 infection, the most remarkable of which is the extraordinarily long asymptomatic period. Here we describe two HIV-2 primary isolat

Identification of HIV-2 strains that do not use CCR5 or CXCR4 to enter in perip...