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The extracellular small leucine-rich proteoglycan biglycan is a key player in g...

Pinto, F; Santos-Ferreira, L; Pinto, MT; Gomes, C; Reis, CA

Biglycan (BGN gene), an extracellular proteoglycan, has been described to be associated with cancer aggressiveness. The purpose of this study was to clarify the clinical value of biglycan as a biomarker in multiple independent GC cohorts and determine the in vitro and in vivo role of biglycan in GC malignant features. We found that BGN is commonly over-expressed in all analyzed cohorts, being associated with di...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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