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Coreceptor Usage by HIV-1 and HIV-2 Primary Isolates: The Relevance of CCR8 Che...

Calado, M; Matoso, P; Santos-Costa, Q; Espirito-Santo, M; Machado, J; Rosado, L; Antunes, K; Mansinho, K; Lopes, MM; Maltez, F; Santos-Ferreira, MO

The human immunodeficiency virus replication cycle begins by sequential interactions between viral envelope glycoproteins with CD4 molecule and a member of the seven-transmembrane, G-protein-coupled, receptors' family (coreceptor). In this report we focused on the contribution of CCR8 as alternative coreceptor for HIV-1 and HIV-2 isolates. We found that this coreceptor was efficiently used not only by HIV-2 but...

Date: 2010   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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