2 documents found, page 1 of 1
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
Mannosylated glycans impair normal T-cell development by reprogramming commitme...
Vicente, MM; Alves, I; Fernandes, Â; Dias, AM; Santos-Pereira, B; Pérez-Anton, E; Santos, S; Yang, T; Correia, A; Münster-Kühnel, A; Almeida, ARMT-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic dev...