20 documents found, page 1 of 2
Natural Killer T-like Cells: Immunobiology and Role in Disease
Almeida, Jani-Sofia; Casanova, José M.; Santos-Rosa, Manuel; Tarazona, Raquel; Solana, Rafael; Rodrigues-Santos, PauloCD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differe...
Tumor-Infiltrating Lymphocytes and Cancer Markers in Osteosarcoma: Influence on...
Casanova, José Manuel; Almeida, Jani-Sofia; Reith, John David; Sousa, Luana Madalena; Fonseca, Rúben; Freitas-Tavares, Paulo; Santos-Rosa, ManuelOsteosarcoma (OST) is the most common type of high-grade primary bone tumor, which mainly affects young adults. The current standard of care for OST combines surgical resection with chemotherapy. The clinical outcomes and the current options to treat OST patients are unsatisfactory and novel treatment strategies are needed. The crosstalk between tumor cells and immune cells is essential to the OST microenvironm...
Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implic...
Mendes, João; Rodrigues-Santos, Paulo; Areia, Ana Luísa; Almeida, Jani-Sofia; Alves, Vera; Santos-Rosa, Manuel; Mota-Pinto, AnabelaBackground Preterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, the inflammatory process plays a pivotal role during the pathogenesis of human labor, both in term and preterm deliveri...
The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunoth...
Fortes-Andrade, Tânia; Almeida, Jani-Sofia; Sousa, Luana Madalena; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José ManuelSoft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in c...
Innate Lymphoid Cells in Human Pregnancy
Mendes, João; Areia, Ana Luísa; Rodrigues-Santos, Paulo; Santos-Rosa, Manuel; Mota-Pinto, AnabelaInnate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombi...
Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treat...
Rodrigues-Santos, Paulo; López-Sejas, Nelson; Almeida, Jani-Sofia; Ruzičková, Lenka; Couceiro, Patrícia; Alves, Vera; Campos, Carmen; Alonso, CoronaNatural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with tyrosine kinase inhibitors (TKIs) induces durable deep ...
Gene Association with Leprosy: A Review of Published Data
Mazini, Priscila Saamara; Alves, Hugo Vicentin; Reis, Pâmela Guimarães; Lopes, Ana Paula; Sell, Ana Maria; Santos-Rosa, ManuelLeprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the ...
Can membrane progesterone receptor on T regulatory cells explainthe ensuing hum...
Areia, Ana; Vale-Pereira, Sofia; Alves, Vera; Rodrigues-Santos, Paulo; Santos-Rosa, Manuel; Moura, Paulo; Mota-Pinto, AnabelaProgesterone acts as an immunosteroid by contributing to the establishment of a pregnancy-protective milieu. It seems that it is the responsibility of progesterone to evade the inflammatory events that lead to parturition. T regulatory lymphocytes (Treg cells) could further explain the inhibition of the inflammatory mechanisms that lead to labour through the rapid action of progesterone on this cell subset. We ...
Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betu...
Sousa, Maria C.; Varandas, Raquel; Santos, Rita C.; Santos-Rosa, Manuel; Alves, Vera; Salvador, Jorge A. R.Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries, affecting more than 12 million people. The treatment consists in pentavalent antimony compounds, amphotericin B, pentamidine and miltefosine, among others. However, these current drugs are limited due to their toxicity, development of biological resistance, length of treatment and high cost. Thus, it is important to continue the sear...
Regulatory T Cells in Elderly Patients With Asthma
Mota-Pinto, Anabela; Todo-Bom, Ana; Alves, Vera; Santos, Alexandra; Santos-Rosa, ManuelBackground: Airway walls in asthma present an accumulation of activated cells that determine bronchial structural changes and disease progression and severity. During the aging process, the immunoinflammatory response changes as a consequence of chronic antigenic stress. Objective: To evaluate T-cell subsets with regulatory functions associated with asthma in elderly patients. Methods: A group of 153 individual...