Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq, grant numbers 27724/2018-2 and 307564/2017-7), Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES, grant numbers 88887.200500/2018-00 and 88881.172137/2018-01), and Pr?-reitoria de Pesquisa da Universidade Federal do Par? (PROPESP?UFPA, s/n); Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.; ...
Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocyte...