128 documents found, page 1 of 13
Gadoteric acid and gadolinium exposure – what is the impact on kidney gene expr...
Coimbra, Carla; Rocha, Susana; Viana, Sofia D.; Rebelo, Rute; Valente, Maria João; Catarino, Cristina; Belo, Luís; Bronze-da-Rocha, Elsa; Reis, FlávioBackground: The nephrotoxicity of gadolinium [Gd (III)] has been reported, raising concerns about the safety of gadolinium-based contrast agents (GBCA). Gd (III) exposure, in renal tubular cells (HK-2), causes apoptosis, and leads to upregulation of genes related to lipogenesis/lipolysis and to signaling pathways related to inflammation/hypoxia [1].Gadoteric acid (Gd-DOTA), a macrocyclic GBCA, appears to be one...
Gadolinium and gadoteric acid exposure induce long-term down-regulation in eryt...
Coimbra, Susana; Rocha, Susana; D. Viana, Sofia; Rebelo, Rute; Rocha-Pereira, Petronila; Valente, Maria João; Catarino, Cristina; Bronze-da-Rocha, ElsaBackground: Gadolinium-based contrast agents (GBCA) differ in their potential to release gadolinium [Gd (III)], known to be toxic. Gadoteric acid (Gd-DOTA) is a macrocyclic GBCA, with a more stable structure. After GBCA exposure, Gd (III) retention in red blood cells (RBC) and kidney has been reported [1,2]. Nephrogenic systemic fibrosis, a severe condition found in renal disease patients exposed to GBCA, is as...
Short-term and long-term effects of gadolinium and gadoteric acid exposure on r...
Coimbra, Susana; Rocha, Susana; D. Viana, Sofia; Rebelo, Rute; Rocha-Pereira, Petronila; Valente, Maria João; Catarino, Cristina; Bronze-da-Rocha, ElsaBackground: There are currently concerns about the safety of gadolinium-based contrast agents (GBCA), as they can release gadolinium [Gd (III)], known to be toxic. Free Gd (III) deposition at different organs, as kidney and liver, has been reported [1,2]. We found that Gd (III) promotes inflammation and fibrosis in proximal tubular cells [3]. GBCA with macrocyclic structure, as gadoteric acid (Gd-DOTA), are con...
TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
Lousa, Irina; Reis, Flávio; Viana, Sofia; Vieira, Pedro; Vala, Helena; Belo, Luís; Santos-Silva, AliceThe inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with th...
TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
Lousa, Irina; Reis, Flávio; Viana, Sofia; Vieira, Pedro; Vala, Helena; Belo, Luís; Santos-Silva, AliceThe inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with th...
The Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease ...
Lousa, Irina; Reis, Flávio; Santos-Silva, Alice; Belo, LuísChronic kidney disease (CKD) has been recognized as a global public health problem. Despite the current advances in medicine, CKD-associated morbidity and mortality remain unacceptably high. Several studies have highlighted the contribution of inflammation and inflammatory mediators to the development and/or progression of CKD, such as tumor necrosis factor (TNF)-related biomarkers. The inflammation pathway dri...
Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring o...
Araujo-Silva, Vanessa Caruline; Santos-Silva, Alice; Lourenço, Andressa Silva; Barros-Barbosa, Cristielly Maria; Moraes-Souza, Rafaianne Queiroz [UNESP]Made available in DSpace on 2022-04-29T08:32:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-10; Embryo-fetal exposure to maternal disorders during intrauterine life programs long-term consequences for the health and illness of offspring. In this study, we evaluated whether mild diabetic rats that were given high-fat/high-sugar (HF/HS) diet presented maternal and fetal changes at term pregnancy. Fe...
Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular D...
Coimbra, Susana; Reis, Flávio; Valente, Maria João; Rocha, Susana; Catarino, Cristina; Rocha-Pereira, Petronila; Sameiro-Faria, MariaDyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentratio...
IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch
Abreu, Maria; Miranda, Marta; Castro, M; Fernandes, Iolanda; Cabral, Renata; Santos, Ana Helena; Fonseca, Sonia; Rodrigues, João; Leander, MagdalenaThe itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients wi...
New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the ...
Lousa, Irina; Reis, Flávio; Beirão, Idalina; Alves, Rui; Belo, Luís; Santos-Silva, AliceThe prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality rate continues to be unacceptably high. The biomarkers currently used in clinical practice are considered relevant when there is already significant renal impairment compromising the early use of potentially successful therapeutic interventions. More sensitive and specific biomarkers to detect CKD earlier on and improve pa...